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 CASE REPORT
Year : 2003  |  Volume : 40  |  Issue : 4  |  Page : 140-143

Early relapse after non myeloablative allogeneic stem cell transplantation in a patient with acute promyelocytic leukemia in complete molecular remission


Service d'Hematologie Clinique, Hopital Edouard Herriot, 69437 Lyon cedex 03, France

Correspondence Address:
Xavier Thomas
Service d'Hematologie Clinique, Hopital Edouard Herriot, 69437 Lyon cedex 03
France
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Source of Support: None, Conflict of Interest: None


PMID: 14716110

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We described a 41-year-old patient with acute promyelocytic leukemia (APL) who experienced two successive relapses: one after all-trans retinoic acid (ATRA) treatment and chemotherapy, and another after ATRA treatment and chemotherapy, followed by autologous peripheral blood stem cell transplantation. A third complete remission (CR) was achieved with arsenic trioxide (As2O3) therapy. Mini-transplantation was performed as consolidation therapy. While the patient was in molecular remission at the beginning of conditioning regimen, a new relapse arose after transplantation at time of cell recovery. This raises a potential relationship between relapse and the severe immunosuppression induced by mini-transplantation. To our knowledge, this is the first description of a mini-allograft in an APL patient achieving molecular remission after As2O3 therapy.






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