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 ORIGINAL ARTICLE
Year : 2004  |  Volume : 41  |  Issue : 4  |  Page : 159-161

Pancreatic involvement in Von Hippel-Lindau disease


1 Clinics of Neurosurgery, Haseki Educational Hospital in Istanbul, Turkey
2 Clinics of Internal Medicine, Haseki Educational Hospital in Istanbul, Turkey

Correspondence Address:
Turgay Bilge
Clinics of Neurosurgery, Haseki Educational Hospital in Istanbul
Turkey
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Source of Support: None, Conflict of Interest: None


PMID: 15659868

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BACKGROUND : Involvement of the pancreas in Von Hippel-Lindau disease that is a tumor predisposing syndrome mentioned in literature with some morbid and mortal progression. AIMS : For evaluation the faith of the pancreatic involvemet in VHL disease we analysed our patient population with VHL disease. MATERIALS AND METHODS : 12 of the 56 patients that were evaluated in our institute with the diagnosis of Von Hippel-Lindau disease had pancreatic involvement. They are periodically examined for 5 years follow up period. Their retrospective analysis was accomplished. RESULTS AND CONCLUSIONS : Pancreatic involvement in our patient population disclosed lesions that were multicysts or serous cystadenomas. During follow up period, we did not observe significant morbidity related to pancreatic involvement. Repeated radiological examination of pancreatic lesions disclosed insignificant modifications such as slight increase or decrease in size. Whereas we considered morbidity and mortality related to renal and central nervous system pathologies in VHL disease. Shortly, even pancratic involvement in VHL disease requires close clinical follow up, morbidity and mortality in this case is not severe as in renal and the central nervous system involvement.






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