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 CASE REPORT
Year : 2005  |  Volume : 42  |  Issue : 2  |  Page : 104-106

T- cell prolymphocytic leukemia - A rare case


1 Department of Hematologist, Asian Institute of Oncology, SL Raheja Hospital, Raheja Hospital Marg, Mahim, Mumbai, India
2 Department of Medical Oncology, Asian Institute of Oncology, SL Raheja Hospital, Raheja Hospital Marg, Mahim, Mumbai, India

Correspondence Address:
Sharmila Ghosh
Department of Hematologist, Asian Institute of Oncology, SL Raheja Hospital, Raheja Hospital Marg, Mahim, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.16702

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T- cell Prolymhocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy that is usually reported in the elderly and follows an aggressive course. A 68 year old male presented with a history of weakness and weight loss of two months duration. Clinical examination revealed pallor, enlarged cervical and axillary lymph nodes and splenomegaly. He also had a maculo- papular skin rash. There was marked leucocytosis, anemia and thrombocytopenia (WBC 445 x103sub/ml, Hb 8.5gm/dl, Platelet 25x103/µl) with 60% prolymphocytes in the peripheral blood. Bone marrow was hypercellular with an excess of prolymphocytes. Flow cytometric analysis of the bone marrow showed positivity for CD2, CD3, CD4, CD5 and CD7. T- PLL is a rare T cell disorder with characteristic clinical and laboratory features.Currently, no optimal treatment exists although there has been some success with 2'- deoxycoformycin or Campath-1H






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