Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :371
Small font sizeDefault font sizeIncrease font size
Navigate here
  Search
 
 » Next article
 » Previous article 
 » Table of Contents
  
Resource links
 »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »  Article in PDF (322 KB)
 »  Citation Manager
 »  Access Statistics
 »  Reader Comments
 »  Email Alert *
 »  Add to My List *
* Registration required (free)  

 
  In this article
 »  Abstract
 »  Introduction
 »  Materials and Me...
 »  Discussion
 »  Conclusion
 »  Acknowledgments
 »  Results
 »  References
 »  Article Figures
 »  Article Tables

 Article Access Statistics
    Viewed7642    
    Printed217    
    Emailed0    
    PDF Downloaded727    
    Comments [Add]    
    Cited by others 34    

Recommend this journal

 


 
ORIGINAL ARTICLE
Year : 2005  |  Volume : 42  |  Issue : 2  |  Page : 78-84
 

Desmoplastic small round cell tumor: Extra abdominal and abdominal presentations and the results of treatment


1 Department of Medical Oncology, Tata Memorial Center, Mumbai, India
2 Department of Radiation Oncology, Tata Memorial Center, Mumbai, India
3 Department of Pathology, Tata Memorial Center, Mumbai, India

Correspondence Address:
Chandrika N Nair
Department of Medical Oncology, Tata Memorial Center, Mumbai
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.16696

Rights and Permissions

 » Abstract 

BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare malignant neoplasm of adolescent males. Current multimodality treatment prolongs life and rarely achieves cure. Aim: To review the presenting features, histopathology and outcome of 18 patients with DSRCT treated at a single institution. Setting and Design: This is a retrospective observational study of patients with DSRCT who presented at the Tata Memorial Hospital between January 1994 to January 2005. Materials and Methods: Eighteen patients of DSRCT seen during this period were evaluated for their clinical presentation, response to chemotherapy and other multimodality treatment and overall survival. The cohort of 18 patients included 11 males (61%) and 7 females (39%) with a mean age of 16 years (Range 1½ - 30 years). Majority (83%) presented with abdomino-pelvic disease. The others, involving chest wall and extremities. There were 6 patients (33%) with metastatic disease at presentation. Results:The treatment primarily included a multimodality approach using a combination of multiagent chemotherapy with adjuvant surgery and radiotherapy as applicable. A response rate of 39% (CR-1, PR-6), with chemotherapy was observed. The overall response rate after multimodality treatment was 39% (CR-5, PR-2). The overall survival was poor except in patients who had complete excision of the tumor. Conclusion: Abdomino-pelvic site was the commonest presentation, the disease can occur at other non-serosal surfaces also. Despite aggressive treatment the outcome was poor. However, complete surgical excision seems to provide a better survival.


Keywords: Desmoplastic round cell tumor, Management and outcome


How to cite this article:
Biswas G, Laskar S, Banavali S D, Gujral S, Kurkure P A, Muckaden M, Parikh P M, Nair CN. Desmoplastic small round cell tumor: Extra abdominal and abdominal presentations and the results of treatment. Indian J Cancer 2005;42:78-84

How to cite this URL:
Biswas G, Laskar S, Banavali S D, Gujral S, Kurkure P A, Muckaden M, Parikh P M, Nair CN. Desmoplastic small round cell tumor: Extra abdominal and abdominal presentations and the results of treatment. Indian J Cancer [serial online] 2005 [cited 2017 Jul 21];42:78-84. Available from: http://www.indianjcancer.com/text.asp?2005/42/2/78/16696



 » Introduction Top


Desmoplastic small round cell tumor is a rare malignant neoplasm. It is characterized by a distinct immunohistochemical profile and a recurrent, specific, chromosomal translocation. It is an aggressive and often misdiagnosed neoplasm of children and young adult. [1],[2]

This tumor has predilection for involvement of the peritoneum. CT features are frequently multiple bulky heterogeneous and necrotic soft tissue masses in the abdomen, usually without any obvious organ base. It is sometimes associated with ascites, adenopathies and liver metastases.

Typically, tumors consist of small, undifferentiated cells or spindle cells invested within an abundant desmoplastic stroma. Immunohistochemical studies show polyphenotypic differentiation with expression of epithelial, neural and muscle markers. [1]

A recurrent specific chromosomal abnormality t (11:22) (p13:q12) has been reported in DSRCT.[3] The breakpoints in this translocation involve two genes EWS, which is altered in the t (11:22) (q24:q12) rearrangement characteristic of the Ewing's family of tumors and WT1, which is a Wilms tumor gene. EWS-WT1 chimeric transcripts are considered diagnostic of this disease. [4],[5]

Current treatment protocols include multiagent chemotherapy and adjuvant surgery and radiotherapy. [6],[7] Several chemotherapy regimens including alkylating agents and aggressive chemotherapy regimen followed by myeloblative therapy and stem cells rescue have been tried.[8] However, the emphasis is on achieving a complete and durable response. We report our experience in the management of DSRCT at our center.


 » Materials and Methods Top


18 patients diagnosed as DSRCT at our institute for management during the period 1994 to 2005 are included this analysis. The diagnosis was based on routine histopathology and the radiological findings. Histopathological evaluation of tumor was done using H & E Microscopy and Immunohistochemistry (IHC). IHC was done for eleven cases. Complete physical and radiological evaluation and metastatic workup using CT scan Thorax/Abdomen/Pelvis, Bone scan, Bone marrow aspiration and biopsy was done for most patients. 6 patients had metastatic disease at presentation. The chemotherapy schedules received by the patients are documented in [Table - 1]. At the end of 8-9 weeks of induction chemotherapy, patients were evaluated for local treatment when feasible. Surgery alone or in combination with radiotherapy was used for local treatment. This was followed by maintenance chemotherapy. The outcome and survival of these patients are documented in [Table - 2] (C).


 » Results Top


The clinical, radiological, treatment received and the outcome and survival of these patients are shown in the [Table - 2] (A, B, C).

The age ranged from 1½ year to 30 years. Ten patients were in the pediatric age group ( < 15 years) and seven were females. Fifteen patients presented with abdomino-pelvic swellings, of which 3 had ovarian mass. One patient had chest wall swelling (Case no. 7) and another patient had an ulcerative mass in the palm of the right hand (Case no. 9). There was no bone marrow involvement among 15 patients done. Bone scan was abnormal in one patient among the 11 patients done. LDH was raised in 6 out of 8 cases done, which probably signify disease load. In cases 13 and 15 we did pre-treatment CA.125, which were significantly raised. We could perform diagnostic EWS-WT1 in case no.17 was positive. The response seen with chemotherapy was 39% (CR-1, PR-6). One had Stable disease and rest was considered to have Progressive disease including those not evaluable for response. In total there were 8 surgeries (Outside-4, TMH-4). There were only 3 complete excision including negative cut margins. 4 patients received radiotherapy including one that received Stereotactic technique. The details of the three unusual primary site of involvement (Case no: 7, 9 & 18) are as follows:

Case no. 7

CT scan revealed a soft tissue mass in the left lower lateral chest wall encasing the lateral portion of the left 9th rib which showed sclerosis and speculated periosteal reaction. The intra thoracic component of the mass was larger than the extra thoracic component. There was no evidence of calcification or ossification [Figure - 1] a. On histopathology [Figure - 3] a & b the tumor cells were positive for CK, EMA, Vimentin, Desmin, NSE, Myoglobin and was negative for S100 and LCA. A diagnosis of DSRCT was made in view of the polyphenotypic expression by the tumor cells. With induction of EFT 2001 protocol [Table - 1], the tumor showed partial response [Figure - 1]b. Complete excision of the tumor was then done. The histopathology of the specimen showed residual tumor and showed divergent differentiation predominantly peripheral neuroectodermal and also epitheloid differentiation with CK being positive. The cut margins were positive for tumor. He then received radiotherapy (5040cGy) followed by maintenance therapy of EFT 2001 protocol. CT scan at 24 months is depicted in [Figure - 1] c. At 57 months (April 2005) he is alive and disease free.

Case no. 9

A 2½-year-old female child presented with a large ulcerative mass in the palm of the right hand. The biopsy revealed high grade malignant tumor with tumor cells showing varied morphology from round to oval to epitheloid features and no desmoplasia was seen. The tumor cells were positive for Cytokeratin, Vimentin, NSE and Chromogranin and were negative for Desmin, MyoD, Myoglobin, CD 30, HMB 45, CD20, and MIC 2. This patient had poor response to chemotherapy schedule ie. VAC regimen [Table - 1]. She underwent above wrist amputation. The histopathology of tumor showed epithelial and mesenchymal markers. She was continued on maintenance chemotherapy. However after 4½ months she developed right axillary mass. This mass was excised along with the nodes. The histopathology of the mass showed high-grade malignant round cell tumor showing polyphenotypic expression and the tumor showed extensive desmoplasia. The nodes were negative for any malignant cells. The child did not receive further treatment.

Case no. 18

This one and half year old female child presented with a large well defined soft tissue mass seen predominantly along postero-lateral aspect of left thigh with lamellated type of periosteal reaction seen involving the entire shaft of femur. The histopathology was suggestive of DSRCT. She received 3 cycles of induction treatment of RCT-II and subsequently lost to follow up.

Response was seen in 7 (n = 18) patients. CR achieved in one and PR in six patients. One had stable disease. Seven had documented progressive disease and 3 patients were not evaluable for response and have been considered to have progressive disease.

Complete excision of the mass was also possible in case no 3. It was found to be an ovarian mass and there was no residual viable tumor. She was continued on 2 more cycles of chemotherapy. At 48 months, she was found to be disease free. Case no. 10 underwent upfront surgery. She had excision of the ovarian mass, excision of mesentery along with the nodules. The liver metastasis also showed response to chemotherapy. The liver metastasis [Figure - 2] a was treated with using Extracranial Stereotactic Radiotherapy technique delivering a dose of 28Gy in 4 # @ 7Gy per # x 2 #/week. At 41 months (March 2005) she is alive and disease free. Case no. 14 presented with ascitis, peritoneal deposits, liver and splenic involvement. Post EFT-2001 protocol induction, he attained PR. Subsequently, completed EFT-2001 protocol maintenance. Post planned treatment PET scan showed diffuse uptake in liver and one focus in spleen. He was then started on oral chemotherapy with Etoposide, Thioguanine and Tamoxifen.

Overall survival has been poor except in the 3 cases where complete excision was possible. Other cases had disease progression locally. The median overall survival is 6.5 months (Range 1-57 m).


 » Discussion Top


We are reporting unusual sites - chest wall, hand, thigh and ovary besides the common sites and the clinical outcome. Similar to all the series reported so far, the abdomino-pelvic site was the commonest site of presentation. Of these 3 cases primarily seems to be arising from the ovary. Other sites Pleura, Para-testicular, Lung, Ovary, thorax, intracranial, soft tissue, bone of the hand and Sino-nasal regions have been reported.[9],[10],[11],[12],[13],[14],[20] DSRCT is commonly reported in children and young adults and male predominance is noted. [6] In our series also male predominance was seen. A high serum CA 125 level may be a specific marker for DSRCT, and thus may permit early diagnosis and treatment of this fast-growing tumor. [21],[22] We have done in 2 patients at baseline and it was found to be significantly raised.

Most patients presented with extensive local disease. Distant metastases were seen in six patients. The most common site of distant metastases was Liver[18] (n=3/6). None had bone marrow involvement.

The diagnosis of DSRCT may be suspected in young men with multiple bulky heterogeneous peritoneal soft tissue mass. Imaging is useful for staging and also for guided biopsies. [18]

Markers for multilineage differentiation has been reported by Lae ME et al. [15] This group has found these tumors to be positive for Desmin (Dot pattern) in 81%, WT1 in 91%, Keratin in 87%, and Neuron Specific Enolase in 84% of the cases. The EWS-WT1 gene fusion transcript was detected in 29 of 30 times. Our patient (Case no. 9) showed polyphenotypic differentiation markers but did not show desmoplasia. However, the metastatic axillary mass later showed extensive desmoplasia along with polyphenotypic expression.

They require aggressive multimodality therapy.[18] Intensive chemotherapy and complete excision of the tumor would be required to achieve long term disease free survival. Often surgery is not feasible especially in the abdomino- pelvic tumors due to the extensive involvement. Whole abdomino-pelvic irradiation (WAPI) has been reported by Goodman KA et al, [16] as a novel approach for the residual disease following aggressive chemotherapy and debulking surgery. However, the overall survival and relapse free survival rate reported by them at 3 years were 48% and 19% respectively. Aggressive multimodality treatment followed by high dose Busulphan with autologous rescue resulting in a disease free survival of only 19 months post transplant is also reported. [8] Successful clinical response was reported by Philip M Rosoft et al with Irinotecan and hence suggests trials with Irinotecan alone or in combination. [17]

Current treatment prolongs life and rarely achieves cure. Neoadjuvant chemotherapy, greater than 90% tumor debulking, and radiotherapy have been shown to prolong survival. Future efforts must focus on cell-specific treatment protocols. [19]

The demerits of this analysis are absence of specific cytogenetics, non-uniformity of protocol and few aggressive surgeries.


 » Conclusion Top


Though abdomino-pelvic site is the commonest site of DSRCT, this malignancy can occur at other sites which are not associated with serosal surface and thus the histogenesis of this tumor still remains obscure.

Our experience shows that some degree of chemo-sensitivity is observed in DSRCT. However a complete surgical excision seems to improve survival. Results of treatment using current combined modality treatment remain unsatisfactory. There is a definite need to further risk stratify thus develop techniques and regimens for improving outcome.


 » Acknowledgments Top


We are thankful to Dr. S. V Kane, Professor, Pathology for doing the electron microscopy in case no 3.

 
 » References Top

1.Gerald WL, Miller HK, Battifora H, Miettinen M, Silva EG, Rosai J. Intra-abdominal desmoplastic small round cell tumor. Report of 19 cases of a distinctive type of high-grade poly phenotypic malignancy affecting young individuals. Am. J Surg. Pathol 1991;15: 499-513.  Back to cited text no. 1    
2.Frappaz D, Bouffet E, Dolbeau D, Bouvier R, Carrie C, Louis D, et al . Desmoplastic small round cell tumor of the abdomen. Cancer 1994;73: 1753-1756.  Back to cited text no. 2  [PUBMED]  
3.Biegel JA, Conard K, Brooks JJ. Translocation (11:22) (p13:q12) in intra-abdominal desmoplastic small round cell tumor. Cancer 1993;7:119-21.  Back to cited text no. 3  [PUBMED]  
4.Rodriguez E, Sreekantaiah C, Gerald W, Reuter VE, Motzer RJ, Chaganti RS. A recurring translocation t (11:22) (P13:q11: 2) characterizes intra-abdominal desmoplastic small round cell tumors. Cancer Genet cytogenet 1993;69:17-21.   Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Gerald WL, Rosai J, Ladanyi M. Characterization of the genomic break point and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor. Proc. Natl. Acad. Sci. USA. 1995;92:1028-32.  Back to cited text no. 5    
6.Kushner B H, LaQuaglia MP, Wollner N, Meyers PA, Lindsley KL, Ghavimi F, et al . Desmoplastic small round cell tumor prolonged progression free survival with aggressive multimodality therapy. J Clin. Oncol 1996;14:1526-31.   Back to cited text no. 6    
7.Marina NM, Pappo AS, Parham DM, Cain AM, Rao BN, Poquette CA, et al . Chemotherapy dose intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round blue cell tumors: a feasibility study at St. Jude children's Research Hospital. J Clin. Oncol 1999;17:180-90.  Back to cited text no. 7    
8.Mazuryk M, Paterson AH, Temple W, Arthur K, Crabtree T, Stewart DA. Benefit of aggressive multimodality therapy with autologous stem cell support for intra abdominal desmoplastic small round cell tumor. Bone marrow Transplant 1998;21:961-3.  Back to cited text no. 8    
9.Parkash V, Gerald WL, Parma A, Miettinen M, Rosai J. Desmoplatic small round cell tumor of the pleura. Am J Surg. Pathol 1995;19:659-65.   Back to cited text no. 9    
10.Cummings OW, Ulbright TM, Young RH, Del Tos AP, Fletcher CD, Hull MT. Desmoplastic small round cell tumors of the para-testicular region. A report of six cases. Am J Surg. Pathol 1997;21:219-25.   Back to cited text no. 10    
11.Syed S, Haque AK, Hawkins HK, Sorensen PH, Cowan DF. Desmoplastic small round cell tumor of the lung. Arch Pathol Lab. Med 2002;126:1226-8.  Back to cited text no. 11    
12.Parker LP, Duong JL, Wharton JT, Malpica A, Silva EG, Deavers MT. Desmoplastic small round cell tumor: report of a case presenting as a primary ovarian neoplasm. Eur. J Gynaecol. Oncol 2002;23:199-202.  Back to cited text no. 12    
13.Elhajj M, Mazurka J, Daya D. Desmoplastic small round cell tumor presenting in the ovaries: report of a case and review of the literature. Int J Gynecol Cancer 2002;12:760-3.  Back to cited text no. 13    
14.Finke NM, Lae M E, Lloyd RV, Gehani SK, Nascimento AG. Sino-nasal desmoplastic small round cell tumor a case report. Am J Surg. Pathol 2002;26:799-803.  Back to cited text no. 14    
15.Lae ME, Roche PC, Jin L, Lloyd RV, Nascimento AG. Desmoplastic round cell tumor: a clinico-pathologic immohistochemical and molecular study of 32 tumors. Am J Surg. Pathol 2002;26:823-35.  Back to cited text no. 15    
16.Goodman KA, Wolden SL, La Quaglia MP, Kushner BH. Whole abdomino-pelvic radiotherapy for desmoplastic small round cell tumor. Int. J Radiat. Oncol. Biol. Phys. 2002;1:170-6.   Back to cited text no. 16    
17.Rosoff PM, Bayliff S. Successful clinical response to Irinotecan in Desmoplastic round blue cell tumor. Medical and Pediatric Oncology 1999;33:500-3.  Back to cited text no. 17    
18.Malik Chouli, Juliette Viala, Clarisse Dromain, Karim Fizazi, Pierrw Duvillard, Daniel vanel. Intra-abdominal DSRCT: CT findings & clinico-pathological correlation in 13 cases. European Journal of Radiology 2004;1-5.  Back to cited text no. 18    
19.Dave R. Lal, Wendy T. Su, Suzanne L. Wolden, Kenneth C. Loh, Shakeel Modak, Michael P. La Quaglia. Results of multimodal treatment for desmoplastic round cell tumors. Journal of Pediatric Surgery 2005;40:251-5.  Back to cited text no. 19    
20.Gerald WL, Ladanyi M, de Alava E, Cuatrecasas M, Kushner BH, LaQuaglia MP, et al . Clinical, pathologic, and molecular spectrum of tumors associated with t (11; 22) (p13; q12): desmoplastic round cell tumor and its variants. JCO 1998;16:3028.  Back to cited text no. 20    
21.Yoshizawa J, Maie M, Eto T, Higashimoto Y, Saito T, Horie H, et al . A case of intra-abdominal desmoplastic small-round-cell tumor with elevated serum CA125. Pediatr Surg Int. 2002;18:238-40.  Back to cited text no. 21    
22.Fizazi K, Farhat F, Theodore C, Rixe O, Le Cesne A, Comoy E, et al . Ca125 and neuron-specific enolase (NSE) as tumor markers for intra-abdominal desmoplastic small round-cell tumors. Br J Cancer. 1997;75:76-8.  Back to cited text no. 22    


    Figures

[Figure - 1], [Figure - 2], [Figure - 3]

    Tables

[Table - 1], [Table - 2]

This article has been cited by
1 Bilateral Presentation of Pleural Desmoplastic Small Round Cell Tumors: A Case Report
You Sun Won,Jai Soung Park,Sun Hye Jeong,Sang Hyun Paik,Heon Lee,Jang Gyu Cha,Eun Suk Koh
Journal of the Korean Society of Radiology. 2015; 72(4): 295
[Pubmed] | [DOI]
2 Desmoplastic small round cell tumor 20 years after its discovery
Jaume Mora,Shakeel Modak,Nai-Kong Cheung,Paul Meyers,Enrique de Alava,Brian Kushner,Heather Magnan,Oscar M Tirado,Michael Laquaglia,Marc Ladanyi,Juan Rosai
Future Oncology. 2015; 11(7): 1071
[Pubmed] | [DOI]
3 Desmoplastic small round cell tumor: A rare cause of a progressive brachial plexopathy
Jan Mathys,Istvan Vajtai,Esther Vögelin,Dieter R. Zimmermann,Christoph Ozdoba,Ekkehard Hewer
Muscle & Nerve. 2014; 49(6): 922
[Pubmed] | [DOI]
4 Abdominal Desmoplastic Small Round Cell Tumor: Multimodal Treatment Combining Chemotherapy, Surgery, and Radiotherapy is the Best Option
Charles Honoré,Koceila Amroun,Laurence Vilcot,Olivier Mir,Julien Domont,Philippe Terrier,Axel Le Cesne,Cecile Le Péchoux,Sylvie Bonvalot
Annals of Surgical Oncology. 2014;
[Pubmed] | [DOI]
5 Desmoplastic small round cell tumour: the radiological, pathological and clinical features
Robert Thomas,Gajan Rajeswaran,Khin Thway,Charlotte Benson,Khawaja Shahabuddin,Eleanor Moskovic
Insights into Imaging. 2013; 4(1): 111
[Pubmed] | [DOI]
6 Desmoplastic small round cell tumour: The radiological, pathological and clinical features
Thomas, R. and Rajeswaran, G. and Thway, K. and Benson, C. and Shahabuddin, K. and Moskovic, E.
Insights into Imaging. 2013; 4(1): 111-118
[Pubmed]
7 Analysis of Clinicopathological Features and Prognostic Factors of Desmoplastic Small Round Cell Tumor
Jinnan Zhang,Haiyan Xu,Fang Ren,Yijin Yang,Bin Chen,Fengchun Zhang
Pathology & Oncology Research. 2013;
[Pubmed] | [DOI]
8 Desmoplastic small round cell tumors with EWS-WT1 fusion transcript in children and young adults
Pascale Philippe-Chomette, Nabil Kabbara, Nicolas Andre, Gaelle Pierron, Aurore Coulomb, Valérie Laurence, Jean-Yves Blay, Olivier Delattre, Gudrun Schleiermacher, Daniel Orbach
Pediatric Blood & Cancer. 2012; 58(6): 891
[VIEW] | [DOI]
9 Management of desmoplastic small round-cell tumors in children and young adults
Jordan, A.H. and Pappo, A.
Journal of Pediatric Hematology/Oncology. 2012; 34(SUPPL. 2): S73-S75
[Pubmed]
10 Management of Desmoplastic Small Round-cell Tumors in Children and Young Adults
Andrea Hayes Jordan,Alberto Pappo
Journal of Pediatric Hematology/Oncology. 2012; 34: S73
[Pubmed] | [DOI]
11 Desmoplastic small round cell tumor of the abdomen: A case report and literature review of therapeutic options
Hafida Benhammane,Leila Chbani,Abdelmalek Ousadden,Ouadii Mouquit,Siham Tizniti,Afaf Riffi Amarti,Nouafal Mellas,Omar El Mesbahi
Health. 2012; 04(04): 207
[Pubmed] | [DOI]
12 Updates on the multimodality management of desmoplastic small round cell tumor
Ashwin A. Kallianpur, Nootan K. Shukla, Suryanarayan V.S. Deo, Praveen Yadav, Dillip Mudaly, Rajni Yadav, Ramanathan M. Palaniappan
Journal of Surgical Oncology. 2012; : n/a
[VIEW] | [DOI]
13 Metastatic Desmoplastic Small Round Cell Tumor Controlled by an Anthracycline-Based Regimen: Review of the Role of Chemotherapy
H. Mrabti, W. Kaikani, N. Ahbeddou, H. Abahssain, B. Khannoussi, M. Amrani, H. Errihani
Journal of Gastrointestinal Cancer. 2011;
[VIEW] | [DOI]
14 Whole Abdominopelvic Intensity-Modulated Radiation Therapy for Desmoplastic Small Round Cell Tumor after Surgery
International Journal of Radiation Oncology*Biology*Physics. 2011;
[VIEW] | [DOI]
15 Mediastinal mass-a rare presentation of desmoplastic small round cell tumour
Nayak, H.K. and Vangipuram, D.R. and Sonika, U. and Kar, P. and Kumar, N. and Kapoor, N.
BMJ Case Reports. 2011;
[Pubmed]
16 Multiple abdominal masses: Report of an unusual case
Ramachandran, V. and Patla, K.
Open Surgical Oncology Journal. 2011; 3: 22-23
[Pubmed]
17 A rapidly developing lung mass diagnosed as desmoplastic small round cell tumor
Raizada, N. and Daga, M. and Sinha, N. and Kumar, R. and Nayak, H. and Kamble, N.L. and Garg, S. and Kumar, N.
Lung India. 2011; 28(4): 287-290
[Pubmed]
18 Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy: A case report and review of the literature
Miwa, S. and Kitamura, S. and Shirai, T. and Hayashi, K. and Nishida, H. and Takeuchi, A. and Nojima, T. and Tsuchiya, H.
Anticancer Research. 2010; 30(9): 3769-3774
[Pubmed]
19 Optimal treatment with systemic chemotherapy, complete surgical excison and hyperthermic intraperitoneal chemotherapy for a desmoplastic small round cell tumor in an adult male patient [Traitement optimal par chimiothérapie systémique, chirurgie de résection avec chimiothérapie intrapéritonéale hyperthermique chez un patient présentant une tumeur desmoplastique à cellules rondes du péritoine]
Lauridant-Philippin, G. and Ledem, N. and Lemoine, F. and Gouerant, S. and Guillemet, C. and Michel, P. and Scotte, M. and Di Fiore, F.
Gastroenterologie Clinique et Biologique. 2010; 34(4-5): 321-324
[Pubmed]
20 Intra-abdominal desmoplastic small round cell tumor: Presentation of four cases and review of the literature
Biswal, B.M. and Naik, V.R. and Shamim, S.E.
Indian Journal of Medical and Paediatric Oncology. 2010; 31(1): 24-27
[Pubmed]
21 Intra-abdominal desmoplastic small round cell tumor: Presentation of four cases and review of the literature
Biswal, B.M., Naik, V.R., Shamim, S.E.
Indian Journal of Medical and Paediatric Oncology. 2010; 31(1): 24-27
[Pubmed]
22 Optimal treatment with systemic chemotherapy, complete surgical excison and hyperthermic intraperitoneal chemotherapy for a desmoplastic small round cell tumor in an adult male patient
G. Lauridant-Philippin,N. Ledem,F. Lemoine,S. Gouerant,C. Guillemet,P. Michel,M. Scotte,F. Di Fiore
Gastroentérologie Clinique et Biologique. 2010; 34(4-5): 321
[Pubmed] | [DOI]
23 Paediatric soft tissue tumours: from histology to molecular diagnosis
Zhongxin Yu,David M. Parham
Diagnostic Histopathology. 2009; 15(11): 524
[Pubmed] | [DOI]
24 Paediatric soft tissue tumours: from histology to molecular diagnosis
Yu, Z., Parham, D.M.
Diagnostic Histopathology. 2009; 15(11): 524-530
[Pubmed]
25 Desmoplastic small round cell tumor: Current treatment approach and role of targeted therapy
Sankhala, K.K., Chawla, S.P.
Clinical Advances in Hematology and Oncology. 2009; 7(7): 476-478
[Pubmed]
26 Intra-abdominal desmoplastic small round cell tumour in a 39-year-old man
Manuel González Barón, Álvaro Pinto Marín, María Garrido Arévalo, Andrés Redondo Sánchez, Enrique Espinosa Arranz, Pilar Zamora Auñón
Clinical and Translational Oncology. 2009; 11(11): 770-772
[Pubmed] | [DOI]
27 Desmoplastic small round cell tumour: A review of literature and treatment options
Stuart-Buttle, C.E., Smart, C.J., Pritchard, S., Martin, D., Welch, I.M.
Surgical Oncology. 2008; 17(2): 107-112
[Pubmed]
28 Desmoplastic small round cell tumor - Abdomen
Kinra, P., Pujahari, A.
Indian Journal of Pathology and Microbiology. 2008; 51(3): 449-450
[Pubmed]
29 Desmoplastic small round cell tumor - DSRCT - A case report
Perić, M., Karaman, I., Britvić-Pavlov, S., Tadić, T., Janković, S., Roglić, J., Fridl-Vidas, V., (...), Ledina, D.
Libri Oncologici. 2008; 36(1-3): 53-58
[Pubmed]
30 Desmoplastic small round cell tumour: A review of literature and treatment options
C.E. Stuart-Buttle,C.J. Smart,S. Pritchard,D. Martin,I.M. Welch
Surgical Oncology. 2008; 17(2): 107
[Pubmed] | [DOI]
31 Desmoplastic small round cell tumor of the lung: Case report
Wang, Z.-M., Xiao, W.-B., Zheng, S.-S.
Chinese Medical Journal. 2007; 120(24): 2327-2328
[Pubmed]
32 Desmoptastic small round cell tumor of meckels diverticulum
Qureshi, S.S., Ramadwar, M.R., Viswanathan, S., Bakshi, A.V., Arora, B., Gupta, T., Laskar, S., (...), Kurkure, P.A.
Journal of Clinical Oncology. 2007; 25(22): 3372-3374
[Pubmed]
33 Malignant small round cell tumor of the heart: a diagnostic dilemma
Sophia George,Pradeep Vaideeswar,Shobhana Pandit,Shubhada Kane,Jagdish Khandeparkar
Cardiovascular Pathology. 2007; 16(1): 56
[Pubmed] | [DOI]
34 Malignant small round cell tumor of the heart: a diagnostic dilemma
George, S., Vaideeswar, P., Pandit, S., Kane, S., Khandeparkar, J.
Cardiovascular Pathology. 2007; 16(1): 56-58
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article

    

  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  © 2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow