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 ORIGINAL ARTICLE
Year : 2005  |  Volume : 42  |  Issue : 4  |  Page : 185-190

Effect of preoperative short - course famotidine on TILs and survival in breast cancer


1 Department of Surgery, All India Institute of Medical Sciences, New Delhi, India
2 Department of Surgery, Raja Muthiah Medical College and Hospital, Annamali University, Chidambaram, India
3 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
R Parshad
Department of Surgery, All India Institute of Medical Sciences, New Delhi
India
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Source of Support: None, Conflict of Interest: None


PMID: 16391436

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Background: Histamine receptor antagonists have been shown to induce tumor-infiltrating lymphocytes (TILs) in colonic cancers and improve survival. The role of histamine receptor anatagonists in breast cancer is unclarified. Aim: To evaluate the role of histamine receptor antagonists in inducing (TILs) in breast cancer. Method: Forty-five patients with operable breast cancers (25 cases who received preoperative famotidine and 20 controls) were studied for the effect of famotidine in inducing TILs and survival in breast cancer. Results: Significant TILs were seen in 75% (18/24) of cases as opposed to 35% (7/20) controls. In logistic regression analysis the only variable found to be predictive of TILs was famotidine, odds ratio 7.324 (1.693-31.686) P = 0.008. In Cox's regression presence of TILs was favorably associated with improved disease free survival at a median follow up of 35.56 months. The hazard ratio for disease relapse was 3.327 (1.174-9.426) P = 0.024 in TIL negative as compared to TIL positive patients. Famotidine use alone was not significant in the original model, however, on incorporation of quadrant of involvement in addition to other established prognostic factors in the above multivariate model, it assumed borderline significance with a hazard ratio for disease free survival 3.404 (1.005-11.531, P = 0.049). Conclusions: Preoperative short course famotidine induces TILs in breast cancer. Patients with TILs demonstrable in tumor specimens had an improved disease free survival. Famotidine may improve disease free survival in breast cancer and these findings need validation in larger population subsets.






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