Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :7
Small font sizeDefault font sizeIncrease font size
Navigate here
  Search
 
 » Next article
 » Previous article 
 » Table of Contents
  
Resource links
 »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »  Article in PDF (144 KB)
 »  Citation Manager
 »  Access Statistics
 »  Reader Comments
 »  Email Alert *
 »  Add to My List *
* Registration required (free)  

 
  In this article
 »  Abstract
 »  Introduction
 »  Case Report
 »  Discussion
 »  References
 »  Article Figures

 Article Access Statistics
    Viewed4877    
    Printed120    
    Emailed0    
    PDF Downloaded241    
    Comments [Add]    
    Cited by others 8    

Recommend this journal

 


 
CASE REPORT
Year : 2006  |  Volume : 43  |  Issue : 1  |  Page : 36-38
 

Inflammatory variant of a well-differentiated retroperitoneal liposarcoma: Case report of a rare giant variety


Department of General Surgery, Sir Ganga Ram Hospital, New Delhi - 110060, India

Correspondence Address:
Prateek K Mehrotra
Department of General Surgery, Sir Ganga Ram Hospital, New Delhi - 110060
India
Login to access the Email id


DOI: 10.4103/0019-509X.25774

PMID: 16763361

Get Permissions

 » Abstract 

Inflammatory liposarcoma is a rare variant of a well-differentiated liposarcoma (WDLPS). We present a case of a 37 years old male who had a giant variety of this inflammatory WDLPS. CT scan revealed a large abdomino-pelvic mass abutting the left kidney and pushing the IVC, Aorta and the left ureter across the midline. CT guided FNAC did not reveal any malignant cells. A large 9-kg fibro-fatty mass, which appeared irregular, congested and bosillated was excised. Microscopic picture revealed foci of fibrosis with mature adipose tissue. Lymphocyte and plasma cell infiltrate was abundant along with multi-nucleate giant cells and few lipoblasts. There are no case reports of a giant inflammatory variant of WD-LPS in world literature and this is the first of its kind from the Indian sub-continent. We present a case report of this rare giant variant of inflammatory WDLPS and discuss the review of literature.


Keywords: Retroperitoneal liposarcoma, inflammatory differentiated liposarcoma, giant liposarcoma.


How to cite this article:
Mehrotra PK, Ramachandran C S, Goel D, Arora V. Inflammatory variant of a well-differentiated retroperitoneal liposarcoma: Case report of a rare giant variety. Indian J Cancer 2006;43:36-8

How to cite this URL:
Mehrotra PK, Ramachandran C S, Goel D, Arora V. Inflammatory variant of a well-differentiated retroperitoneal liposarcoma: Case report of a rare giant variety. Indian J Cancer [serial online] 2006 [cited 2014 Nov 24];43:36-8. Available from: http://www.indianjcancer.com/text.asp?2006/43/1/36/25774



 » Introduction Top


Well-differentiated liposarcoma (WDLPS) is a low-grade malignant mesenchymal tumor. It includes the sclerosing, spindle cell, inflammatory, adipocytic and dedifferentiated rare subtypes.[1] WDLPS is the second most common liposarcoma (LPS) after the myxoid variety. Presence of abundant inflammatory cells is uncommon in WDLPS.[2] There are only two small series of 10 cases[2] and 9 cases[3] of inflammatory WDLPS reported in literature. Giant variants of inflammatory retroperitoneal WDLPS have not been reported, though there are case reports of giant LPS containing myxoid and dedifferentiated elements.[4] Till date only one case of an inflammatory WDLPS has been reported from the Indian subcontinent.[5] This is only the 2nd case and first of its kind of a giant variety of retroperitoneal inflammatory WDLPS reported from the Indian subcontinent.


 » Case Report Top


A 37-year-old male presented with epigastric pain for 10 days with gradual increase in weight and abdominal girth over the past 5 years. On examination, a diffused, non-tender, non-mobile mass occupying the whole of the left side of the abdomen could be felt. The margins were ill defined.

His hemogram, renal, liver functions and CEA levels were within the normal range. A contrast enhanced CT scan revealed a large fatty retroperitoneal mass abutting the left kidney causing its malrotation along the horizontal axis with the left ureter being displaced to the right of the spine in its upper 2/3rd [Figure - 1]. The Aorta and IVC were displaced towards the right and the colon was displaced anteriorly. IVP confirmed the findings. An angiogram did not reveal any obvious major arterial feeder. CT guided FNAC of the mass revealed mature adipocytes with no evidence of malignant cells.

Excision of the retroperitoneal tumor was done through a trans-peritoneal approach. The large fat containing retroperitoneal abdomino-pelvic mass was abutting the left kidney and had pushed the bowel anteriorly. Mass was densely adherent to the left Gerota's fascia.

Gross appearance revealed a 35 x 28 x 13 cm irregular bossilated fibro-fatty mass weighing 9-kgs. [Figure - 2] Cut section shows homogenous yellow brown appearance. Microscopic picture revealed mature adipocytes with foci of fibrosis. Abundant inflammatory cell infiltrate of lymphocytes, plasma cells and a few polymorphs were seen. [Figure - 3] A few scattered tumor cells had pale, granular to vacuolated cytoplasm with large hyper-chromatic pleomorphic nuclei along with multi-nucleate giant cells and stray lipoblasts were present. [Figure - 4] The resected margins were free from the tumour. No radiotherapy or chemotherapy has been given in the post-operative period. The patient has been on regular follow up for the past 24 months. There has been no recurrence.


 » Discussion Top


Liposarcomas are commonly found in the thigh and the retro-peritoneum. Their clinical presentation of inflammatory WD-LPS is not significantly different from their commoner counterparts where no inflammatory infiltrate is seen, but at times patients may present with pyrexia of unknown origin.[5] At times the extensive lympho-plasmocytic infiltration mimics an inflammatory pseudotumour and Castlleman's disease.[2] Key histological features encountered are nodular lympho-plasmocytic aggregates containing fibroblastic elements, frequently with plasma cell rich zone and scattered atypical, multi-nucleate cells.[2] There are reports to suggest that T cells are the prominent type[3] but workers have also suggested a predominance of B cells.[2]

Retroperitoneal localization is a significant negative prognostic factor for recurrence. Other factors influencing survival rates are the tumour size, depth, invasion of surrounding structures and completeness of surgical excision. Studies have reported a recurrence rate of 27%.[6] Like most of the sarcomas, lung is the commonest site of metastasis. Other sites of metastasis are vertebra, liver and brain.[6] Radical surgery is the treatment of choice for retroperitoneal sarcomas. Our case did not have any evidence of metastasis and on surgery it was only found to be adherent to the Gerota's fascia. The resected margins were negative. 24 months follow up has not revealed any recurrence or metastasis.

There is a scarcity of reports of giant liposarcomas in world literature. The inflammatory variant of WD-LPS has been underreported in world literature with only two small series documented till date.[2],[3] There has been only one case of inflammatory WD-LPS reported from the Indian subcontinent. This is the first case of a giant retroperitoneal inflammatory WD-LPS being reported.

Giant retroperitoneal LPS of the mixed type weighing 17 kg's[7] and dedifferentiated variety weighing 18 kg's[8] have been reported but there are no reports of a giant inflammatory WD-LPS. The tumour in our case weighed 9 kg's, which is one of the largest reported cases of inflammatory WD-LPS of the retroperitoneum. The mean size of retroperitoneal liposarcomas' reported is 15.7 cm.[9] The tumour in our case was much larger (35 x 28 x 13 cm) than the average reported size.

In conclusion, inflammatory variant of well-differentiated liposarcoma is a rare tumour found mainly in the lower limb and retroperitoneum. This is one of the largest reported cases of an inflammatory WD-LPS of the retroperitoneum.

 
 » References Top

1.Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol 2000;4:252-66.  Back to cited text no. 1  [PUBMED]  
2.Kraus MD, Guillou L, Fletcher CD. Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma. Am J Surg Pathol 1997;21:518-27.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Argani P, Facchetti F, Inghirami G, Rosai J. Lymphocyte-rich well-differentiated liposarcoma: report of nine cases. Am J Surg Pathol 1997;21:884-95.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Maamouri N, Cheikh I, Ouerghi H, Oukaa A, Belkahla N, Mnif E, et al . Giant retroperitoneal liposarcoma. One case report. Rev Med Interne 2005;26:145-8.  Back to cited text no. 4    
5.Rani U, Sharma MC, Pande GK, Kapoor A, Dey AB. Well-differentiated Inflammatory liposarcoma presenting as pyrexia of unknown origin. Assoc Physic India 2001;49:761-3.   Back to cited text no. 5  [PUBMED]  
6.Nijhuis PH, Sars PR, Plaat BE, Molenaar WM, Sluiter WJ, Hoekstra HJ. Clinico-pathological data and prognostic factors in completely resected AJCC stage I-III liposarcomas.Ann Surg Oncol 2000;7:535-43.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]
7.Murphy CG, Winter DC, Broe PJ. Giant mixed type retroperitoneal liposarcoma. Ir Med J 2004;97:178-9.  Back to cited text no. 7  [PUBMED]  
8.Inoue K, Higaki Y, Yoshida H. Giant retroperitoneal liposarcoma. Int J Urol 2005;12:220-2.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]
9.Bradley JC, Caplan R. Giant retroperitoneal sarcoma: A case report and review of the management of retroperitoneal sarcomas. Am Surg 2002;68:52-6.  Back to cited text no. 9  [PUBMED]  


    Figures

[Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4]

This article has been cited by
1 Giant Inflammatory Variant of Well-Differentiated Liposarcoma of Retroperitoneum: A Rare Case Report
Shubha P. Bhat,Kishan H. L. Prasad,Rohan Shetty,Rajesh Ballal,Sunil Y. Kumar,Panna Hegde
Indian Journal of Surgical Oncology. 2013;
[Pubmed]
2 MRI findings of an inflammatory variant of well-differentiated liposarcoma
Kenji Kumagai, Masato Tomita, Yoshihiro Nozaki, Kentaro Sugiyama, Kuniko Abe, Masataka Uetani
Skeletal Radiology. 2010; 39(5): 491
[VIEW]
3 Retroperitoneal well-differentiated inflammatory liposarcoma: a diagnostic dilemma
Kawano, R. and Nishie, A. and Yoshimitsu, K. and Irie, H. and Tajima, T. and Hirakawa, M. and Ishigami, K. and Ushijima, Y. and Okamoto, D. and Yabuuchi, H. and others
Radiation Medicine. 2008; 26(7): 450-453
[Pubmed]
4 Giant retroperitoneal liposarcoma
Herrera-Gómez, Á., Ortega-Gutiérrez, C., Betancourt, A.M., Luna-Ortiz, K.
World Journal of Surgical Oncology. 2008; 6(art no 115)
[Pubmed]
5 Retroperitoneal well-differentiated inflammatory liposarcoma: a diagnostic dilemma
Rinsaku Kawano,Akihiro Nishie,Kengo Yoshimitsu,Hiroyuki Irie,Tsuyoshi Tajima,Masakazu Hirakawa,Kousei Ishigami,Yasuhiro Ushijima,Daisuke Okamoto,Hidetake Yabuuchi,Akinobu Taketomi,Yunosuke Nishihara,Nobuhiro Fujita,Hiroshi Honda
Radiation Medicine. 2008; 26(7): 450
[Pubmed]
6 Inflammatory variant of a well-differentiated retroperitoneal liposarcoma: case report of a rare giant variety.
Mehrotra PK, Ramachandran CS, Goel D, Arora V
Indian journal of cancer. 2006 Jan-Mar; 43(1): 36-8
[Pubmed]
7 Group C beta-hemolytic streptococcal infections in children: nine pediatric cases and review.
Arditi M, Shulman ST, Davis AT, Yogev R
Reviews of infectious diseases. 1989 Jan-Feb; 11(1): 34-45
[Pubmed]
8 Freyæs syndrome.
Harper KE, Spielvogel RL
International journal of dermatology. 1986; 25(8): 524-6
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article

    

  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  © 2007 - Indian Journal of Cancer | Published by Medknow