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Year : 2006  |  Volume : 43  |  Issue : 2  |  Page : 54-59

Is interferon-α and retinoic acid combination along with radiation superior to chemo-radiation in the treatment of advanced carcinoma of cervix?


1 Departments of Gynecologic Oncology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, India
2 Departments of Medical Oncology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, India
3 Departments of Radiation Oncology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, India

Correspondence Address:
P Basu
Departments of Gynecologic Oncology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.25885

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Locally advanced cervical cancers comprise a large majority of the gynecologic cancers in India and other developing countries. Concurrent chemo-radiation has improved the survival of high risk stage I and stage II cervical cancers. There is no evidence that the same survival benefit has been achieved with chemo-radiation in stage III and stage IV disease. Interferon-a and Retinoic acid have synergistic anti-proliferative activity. In combination with radiation, they substantially enhance the sensitivity of the squamous carcinoma cells to radiation. Based on these observations from the in vitro studies, a few clinical trials have evaluated the combination of interferon-a and Retinoic acid, concomitant with radiation, to treat cervical cancers. The results from these early trials were encouraging and the combination had minimal toxicities. However, till date, no phase III randomized controlled trial has been done to evaluate this therapeutic modality.






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