Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :688
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7200    
    Printed181    
    Emailed3    
    PDF Downloaded910    
    Comments [Add]    
    Cited by others 20    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2006  |  Volume : 43  |  Issue : 3  |  Page : 110-116

Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India


1 Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
2 Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
3 Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
4 Primary Health Center, Manimajra, UT, Chandigarh, India
5 Obstetrics and Gynecology Department of General Multispeciality Hospital, Sector - 16, Chandigarh, India

Correspondence Address:
S K Arora
Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.27932

Rights and Permissions

INTRODUCTION: Cervical cancer is the commonest cancer among Indian women. High-risk human papillomavirus (HPV) detection holds the potential to be used as a tool to identify women, at risk for subsequent development of cervical cancer. There is a pressing need for identifying prevalence of asymptomatic cervical HPV infection in the local population. OBJECTIVE: To determine the prevalence of high-risk HPV DNA in women with benign cervical cytology. MATERIALS AND METHODS: Women visiting the gynecology outpatient with varied complaints were subjected to Pap smear. Four hundred and seventy two samples were subjected to polymerase chain reaction, using consensus primers for low and high-risk HPV (types 6, 11, 16, 18, 31 and 33). The samples that were positive for HPV DNA were subsequently assessed for high-risk consensus primers, types 16, 18, 31 and 33 as well as for HPV type 16 and 18. RESULTS: One hundred and seventy four (36.8%) women tested positive for HPV DNA. Thirty nine (8.2%) of the entire cohort tested positive for high-risk HPV. Fifteen samples were positive for type 16, 22 for type 18 and two for both types 16 and 18. A statistically higher prevalence of high-risk HPV was observed in poorly educated and rural groups. No association of HPV prevalence was noted with age, parity and age at marriage. CONCLUSION: The study generates epidemiological data of prevalence of sub-clinical HPV in the women visiting a tertiary care institute as well as peripheral health centres. The data generated will be useful for laying guidelines for mass screening of HPV, treatment and prophylaxis in the local population.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  © 2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow