Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :1968
Small font sizeDefault font sizeIncrease font size
Navigate here
  Search
 
  Next article
  Previous article 
  Table of Contents
  
Resource links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (61 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   References

 Article Access Statistics
    Viewed3022    
    Printed106    
    Emailed0    
    PDF Downloaded260    
    Comments [Add]    
    Cited by others 3    

Recommend this journal

 


 
LETTER TO EDITOR
Year : 2008  |  Volume : 45  |  Issue : 2  |  Page : 72-73
 

Adult T cell leukemia: A typical case from India


Department of Medical Oncology and Hematopathology Laboratory, Tata Memorial Hospital, Dr. E. Borges Road, Parel, Mumbai-400 012, India

Correspondence Address:
P M Parikh
Department of Medical Oncology and Hematopathology Laboratory, Tata Memorial Hospital, Dr. E. Borges Road, Parel, Mumbai-400 012
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.41776

Rights and Permissions



How to cite this article:
Jain P, Gupta S, Prabhash K, Patkar N, Parikh P M. Adult T cell leukemia: A typical case from India. Indian J Cancer 2008;45:72-3

How to cite this URL:
Jain P, Gupta S, Prabhash K, Patkar N, Parikh P M. Adult T cell leukemia: A typical case from India. Indian J Cancer [serial online] 2008 [cited 2019 Oct 16];45:72-3. Available from: http://www.indianjcancer.com/text.asp?2008/45/2/72/41776


Dear Sir,

Adult T-cell leukemia/lymphoma (ATL) is a neoplastic disease of CD4-positive T lymphocytes. Human T-cell leukemia virus type I (HTLV-I) is critical for the development of ATL. [1] HTLV-I is endemic in Japan. [2] ATL has hardly been reported from India. ATL develops in only 2% to 4% of patients who are carriers of the HTLV-1 virus. [3] We describe a case of 22-year-old female who presented in July 2007 with two weeks history of swellings in neck, axilla, groin and extremities with generalized erythematous skin rash and bilateral decrease in hearing. She had pallor, edema feet, oral thrush, generalized lymphadenopathy with hepatospleenomegaly. The complete blood count showed hemoglobin of 8.59 gm/dl a WBC count of 306 109 /L with normal platelets. The peripheral smear showed atypical cleaved lymphocytes 50% (Flower Cells), polymorph 16% and lymphocytes 34%. She had mild azotemia with normal serum calcium but raised serum alkaline phosphatase 591.0 U/L and raised serum LDH 524 U/L. Peripheral blood immunophenotype show negative markers for myeloid, precursor cell, CD10, CD19, CD3, CD5, CD7, cyto CD3, TCR, NK cells and strongly positive for CD2, CD4 and CD25. [4] Bone marrow aspirate and biopsy showed involvement by high grade T cell NHL. Serology for HTLV-1 was positive. Although she was normocalcemic the bone scan showed "super scan appearance". She did not respond to intensive ALL type BFM-90 protocol. She developed extensive pulmonary fungal infection and was subsequently lost to follow-up due to source constraints and expired at home five months after presentation. This case emphasizes that ATL can be seen in a non endemic area like India and has an aggressive course.

 
  References Top

1.Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980;77:7415-9.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Takatsuki K, Matsuoka M, Yamaguchi K. Adult T-cell leukemia in Japan. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:S15-9.  Back to cited text no. 2  [PUBMED]  
3.Taylor GP. The epidemiology of HTLV-I in Europe. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:S8-14.  Back to cited text no. 3  [PUBMED]  
4.Matsuoka M. Human T-cell leukemia virus type I and adult T-cell leukemia. Oncogene 2003;22:5131-40.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]



This article has been cited by
1 Epidemiological aspects and world distribution of HTLV-1 infection
Gessain, A. and Cassar, O.
Frontiers in Microbiology. 2012; 3(NOV)
[Pubmed]
2 HTLV 1 associated adult T cell lymphoma/leukemia a clinicopathologic, immunophenotypic tale of three cases from non-endemic region of south India
Ahmed, F. and Murthy, S.S. and Mohan, M.V.T. and Rajappa, S.J.
Indian Journal of Pathology and Microbiology. 2012; 55(1): 92-96
[Pubmed]
3 Adult T-cell leukemia in India: Report of two cases and review of literature
Karthik, U. and Ganesan, P. and Sagar, T.G. and Cyriac, S. and Majhi, U.
Journal of Cancer Research and Therapeutics. 2011; 7(3): 338-340
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article

    

  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow