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 REVIEW ARTICLE
Year : 2009  |  Volume : 46  |  Issue : 4  |  Page : 288-296

Pancreatic carcinogenesis: The impact of chronic pancreatitis and its clinical relevance


1 Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Mumbai, India
2 Department of General Surgery, General Hospital of Athens, Athens, Greece

Correspondence Address:
S V Shrikhande
Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.55548

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Pancreatic cancer is a devastating disease with a dismal prognosis and early detection remains a challenge. On the background that inflammation is one of the key steps in the development of cancer, it is natural that chronic pancreatitis is considered as one of the etiological factors for the development of pancreatic cancer. However, the process of pancreatic carcinogenesis is a multifactorial phenomenon rather than a process that evolves solely via inflammation. This review attempts to put into perspective the association between different etiological forms of chronic pancreatitis and pancreatic cancer, and the diverse mechanisms operational in the process of pancreatic carcinogenesis. Furthermore, the clinical relevance of the current understanding of the relationship between chronic pancreatitis and pancreatic cancer, especially with regard to the pancreatic head mass of uncertain etiology, is discussed in this review.






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