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 ORIGINAL ARTICLE
Year : 2010  |  Volume : 47  |  Issue : 3  |  Page : 314-316

Hepatoblastoma: Experience from a single center


1 Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India
2 Department of Pediatrics Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India
3 Department of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India
4 Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India

Correspondence Address:
T Singh
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.64724

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Background: The cornerstones of successful treatment of hepatoblastoma (HB) include preoperative chemotherapy followed by complete anatomical resection of tumor, followed by chemotherapy. Advances in chemotherapy in the last 2 decades have been associated with a higher rate of tumor response and possibly a greater potential for resectability. Aims: We analyzed our single center experience with neoadjuvant chemotherapy (NACT) and surgery in HBs. Settings and Design: Our study included all children with HBs who received NACT and underwent surgical excision from January 1997 to July 2004. Materials and Methods: Patient characteristics, clinical features, clinical course, treatment modalities, and long-term outcome were analyzed. Results: There were 9 boys and 3 girls, aged 5-60 months (median age at tumor diagnosis was 24 months). All received NACT containing cisplatin and doxorubicin. Of the 12 children, 9 underwent hepatectomy and among them, 4 patients each had right and left hepatectomy and 1 patient underwent right extended hepatectomy. After surgery, all patients completed rest of the chemotherapy course (total 6 cycles). R0 resection was carried out in all the 9 cases with no life-threatening complications. Conclusions: Our experience of the 9 cases, although less in number, reaffirms the advantages of NACT followed by surgery. The prognosis for patients with resectable tumors is fairly good in combination with chemotherapy.






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