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 ORIGINAL ARTICLE
Year : 2010  |  Volume : 47  |  Issue : 3  |  Page : 317-321

Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population


1 Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad university of Medical Sciences, Mashhad, Iran
2 Omid and Imam Reza hospital, Cancer Research Center, Mashhad, Iran

Correspondence Address:
J Behravan
Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad university of Medical Sciences, Mashhad
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.64723

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Background: The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer. Objectives: The objective of this study was to find out the association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. Materials and Methods: In this study, 48 gastric cancer patients were diagnosed. Genomic DNA was extracted by a salting-out method. The MDR1 polymorphism was studied by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method, using a standard method. Results: The polymorphic homozygote (T/T) genotype showed significantly an association with the incidence of gastric cancer compared with controls (P < 0.05). Conclusions: This study suggests that C3435T polymorphism of the MDR1 gene may be associated with gastric cancer in an ethnic Iranian population.






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