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 SYMPOSIUM
Year : 2011  |  Volume : 48  |  Issue : 1  |  Page : 18-23

Selective internal radiation therapy: 90 Y (yttrium) labeled microspheres for liver malignancies (primary and metastatic)


1 Department of Radiology, Manipal Hospital, Old Airport Road, Bangalore-560 017, India
2 Thambiran Hospital, Near K4 Police Station, Annanagar, Chennai, India
3 Sir Ganga Ram Hospital, Rajendra Nagar, New Delhi-110 060, India

Correspondence Address:
M C Uthappa
Department of Radiology, Manipal Hospital, Old Airport Road, Bangalore-560 017
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.76625

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Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors including carcinoid tumors, lung, breast, sarcoma, colon, hepatocellular and ocular melanoma. Its clinical benefit can be as much as 85%, survival can be doubled and patients with extensive colorectal metastases not amenable to resection or ablation can be offered a 32% chance of surviving for 18 months. Ongoing and future studies will refine our understanding of optimizing patient eligibility, dosage, frequency as well as novel applications.






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