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 REVIEW ARTICLE
Year : 2011  |  Volume : 48  |  Issue : 2  |  Page : 246-251

The role of innate immunity in spontaneous regression of cancer


1 Department of Oral Medicine and Radiology, Rajarajeshwari Dental College, Mysore road, Bangalore, India
2 Department of Oral Pathology, Dr. Syamala Reddy Dental College, Marathahalli, Bangalore, India

Correspondence Address:
J A Thomas
Department of Oral Medicine and Radiology, Rajarajeshwari Dental College, Mysore road, Bangalore
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.82887

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Nature has provided us with infections - acute and chronic - and these infections have both harmful and beneficial effects on the human system. Worldwide, a number of chronic infections are associated with a risk of cancer, but it is also known that cancer regresses when associated with acute infections such as bacterial, viral, fungal, protozoal, etc. Acute infections are known to cure chronic diseases since the time of Hippocrates. The benefits of these fever producing acute infections has been applied in cancer vaccinology such as the Coley's toxins. Immune cells like the natural killer cells, macrophages and dendritic cells have taken greater precedence in cancer immunity than ever before. This review provides an insight into the benefits of fever and its role in prevention of cancer, the significance of common infections in cancer regression, the dual nature of our immune system and the role of the often overlooked primary innate immunity in tumor immunology and spontaneous regression of cancer.






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