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Year : 2011  |  Volume : 48  |  Issue : 3  |  Page : 351-360

The Smad family and its role in pancreatic cancer


1 Cancer Genetics Unit, Hormones and Cancer Group, Kolling Institute of Medical Research, NSW, 2006, Australia
2 Department of General Surgery, Government Medical College and Hospital, Sector-32, Chandigarh, India
3 Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
P Singh
Cancer Genetics Unit, Hormones and Cancer Group, Kolling Institute of Medical Research, NSW, 2006
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.84939

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One of the major signaling pathways that determine the tumor aggression and patient outcome in pancreatic cancer is the transforming growth factor-beta (TGF-ß) pathway. It is inactivated at various levels in pancreatic cancer and plays a dual role in tumor initiation and progression. The Smad family of proteins transduce signals from the TGF-ß superfamily ligands that regulate cell proliferation, differentiation and death through activation of receptor serine/threonine kinases. This review discusses the structure, function and regulation of various participating Smad family members, and their individual roles in determining the progression and outcome of pancreatic cancer patients, with a special emphasis on Smad4.






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