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 MOLECULAR BIOLOGY - REVIEW ARTICLE
Year : 2011  |  Volume : 48  |  Issue : 4  |  Page : 507-512

Epigenetic changes in tumor microenvironment


Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
P Dey
Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.92246

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The drama of cancer is not the solo performance of the malignant cells. Microenvironment of the tumor has significant contribution in carcinogenesis. Recent evidences show distinct gene promoter methylation in stromal cells of various malignant and pre-malignant tumors. These changes probably create unique tumor microenvironment, which is responsible for initiation, proliferation, invasion, and metastasis of tumor cells. In this mini review the role of epigenetic changes of tumor microenvironment in carcinogenesis has been discussed.






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