Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :957
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3013    
    Printed113    
    Emailed4    
    PDF Downloaded362    
    Comments [Add]    
    Cited by others 5    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2012  |  Volume : 49  |  Issue : 1  |  Page : 176-180

Spectrum of malignancies among HIV-infected patients in South India


1 Division of Infectious Diseases, Department of Medicine and Community Health, Alpert Medical School, Brown University/Miriam Hospital, RI, USA
2 YR Gaitonde Centre for AIDS Research and Education, Chennai, India

Correspondence Address:
K K Venkatesh
Division of Infectious Diseases, Department of Medicine and Community Health, Alpert Medical School, Brown University/Miriam Hospital, RI
USA
Login to access the Email id

Source of Support: Brown University's AIDS International Research and Training Program of the Fogarty International Center at the National Institutes of Health (NIH), USA (grant no. D43TW00237), ACTG-ICTU/ NIH-Chennai site grant for supporting this study., Conflict of Interest: None


DOI: 10.4103/0019-509X.98947

Rights and Permissions

Introduction: The current study examines the spectrum of malignancies among HIV-infected South Indians enrolled in a clinical care program. Materials and Methods: We conducted a nested matched case-control study among 42 HIV-infected cases who developed cancer and 82 HIV-infected controls between 1998 and 2008 at a tertiary care HIV care program in South India. Results: The most common types of cancer included non-Hodgkin's lymphoma (38.1%), Hodgkin's lymphoma (16.7%), squamous cell carcinoma (14.3%), and adenocarcinoma (14.3%). The median duration of time from HIV infection to cancer diagnosis was 549 days [interquartile range (IQR): 58-2013]. The nadir CD4 cell count was significantly lower in cases compared to controls (134 cells/μl vs. 169 cells/μl; P = 0.015). Cancer patients were more likely to have a more advanced HIV disease stage at the time of cancer diagnosis compared to control patients (Stage C: 90.5% vs. 49.4%; P<0.0001). Significantly more cancer patients were receiving antiretroviral treatment relative to control patients at the time of cancer diagnosis (92.9% vs. 66.3%; P=0.001). Conclusions: HIV-infected patients who developed cancer had more advanced immunodeficiency at the time of cancer diagnosis and a lower nadir CD4 cell count. It is possible that with the continued roll-out of highly active antiretroviral therapy in India, the incidence of HIV-associated malignancies will decrease.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  © 2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow