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 MINI SYMPOSIUM: STROMAL TUMOR
Year : 2013  |  Volume : 50  |  Issue : 1  |  Page : 41-45

Primary extragastrointestinal stromal tumors: A clinicopathological and immunohistochemical study-A tertiary care center experience


1 Department of Pathology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh 517 507, India
2 Department of Surgical Oncology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh 517 507, India
3 Department of Surgical Gastroenterology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh 517 507, India

Correspondence Address:
R Patnayak
Department of Pathology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh 517 507
India
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Source of Support: Patnayak R,Jena A,Parthasarathy S,Durgaprasad P,Reddy MK,Chowhan AK,Rukhamangadha N,Phannendra BV.., Conflict of Interest: None


DOI: 10.4103/0019-509X.112298

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Background: Extra gastrointestinal stromal tumors (EGIST) are uncommon compared to their gastrointestinal counterparts. EGISTs involve omentum, mesentery, retroperitoneum, pancreas, and pelvis. Materials and Methods: Ten EGISTs were analyzed in this study from January 1995 to November 2011. They were analyzed with respect to clinical features, imageological, histopathological, and immunohistochemical findings. The immunohistochemical stains used were Smooth muscle actin (SMA), Desmin, S-100 protein, CD34 and CD-117. Results: There was slight female preponderance with wide age range. Four of the tumors were in retroperitoneum, three in mesentery, and two in omentum and one in pelvis. Histopathologically majority were spindle cell tumors. Immunohistochemically CD117 was consistently positive followed by CD34. Smooth muscle actin was positive in eight cases, S-100 protein and desmin were positive in two cases each. Conclusion: EGISTs are rare and should be considered in the differential diagnosis of the mesenchymal tumors and immunohistochemistry helps to confirm the diagnosis. Further study with better follow-up is desired to characterize these uncommon tumors.






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