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 ORIGINAL ARTICLE
Year : 2013  |  Volume : 50  |  Issue : 3  |  Page : 239-244

Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast


1 Department of Pathology, King George's Medical University UP, Lucknow, Uttar Pradesh, India
2 All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, (Formerly Professor, Department of Surgery, King George's Medical University UP, Lucknow, Uttar Pradesh), India
3 Central Drug Research Institute, Lucknow, India
4 Department of Pathology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India

Correspondence Address:
M M Goel
Department of Pathology, King George's Medical University UP, Lucknow, Uttar Pradesh
India
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Source of Support: Indian Council of Medical Research, New Delhi (No. 5/13/26/2007/NCD III), Conflict of Interest: None


DOI: 10.4103/0019-509X.118744

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Background: Aim of this study was to investigate the prognostic significance of CD3+ TILs in infiltrating ductal carcinoma (IDC) of the breast. Materials and Methods: Immuno-histochemistry was done with CD3 antibodies in tissue sections of 127 breast cancer patients, and CD3+ intra-tumoral and stromal TILs were counted in relation to clinico-pathological variables. Results: Intra-tumoral and stromal CD3+ TILs were significantly associated with positive lymph node status (P = 0.006, P = 0.043, respectively) without significant association with age, menopausal status, family history, and hormonal status. The higher CD3 intra-tumoral and stromal counts both showed significant association with good prognosis (P = 0.039, P = 0.044, respectively). The intra-tumoral count was higher than stromal count and was independently associated with disease-free survival in stage I and II cancer (P = 0.021). Conclusions: CD3+ TILs may serve as independent marker of good prognosis in IDC breast. The findings of this study need further validation on a larger sample size.






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