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  Table of Contents  
LETTER TO EDITOR
Year : 2014  |  Volume : 51  |  Issue : 3  |  Page : 391-392
 

Detection and response evaluation of penile metastasis from urinary bladder carcinoma demonstrated by F-18 FDG PET/CT


1 Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication10-Dec-2014

Correspondence Address:
Dr. B R Mittal
Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.146772

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How to cite this article:
Kamaleshwaran K K, Mittal B R, Santhosh S, Kashyap R, Bhattacharya A, Mete U K. Detection and response evaluation of penile metastasis from urinary bladder carcinoma demonstrated by F-18 FDG PET/CT. Indian J Cancer 2014;51:391-2

How to cite this URL:
Kamaleshwaran K K, Mittal B R, Santhosh S, Kashyap R, Bhattacharya A, Mete U K. Detection and response evaluation of penile metastasis from urinary bladder carcinoma demonstrated by F-18 FDG PET/CT. Indian J Cancer [serial online] 2014 [cited 2019 Sep 21];51:391-2. Available from: http://www.indianjcancer.com/text.asp?2014/51/3/391/146772


Sir,

We report the findings on positron emission tomography-computed tomography (PET-CT) fusion imaging of penile metastasis in a 59-year-old man with a history of transitional cell carcinoma (TCC) of the urinary bladder previously treated with cystectomy and orthotopic neobladder. The patient presented with an indurated ulcer in the base of penis after 4 months of curative resection. He was subjected to PET-CT imaging 45 minutes after intravenous administration of 10 mCi of (F-18) fluorodeoxyglucose (FDG). PET demonstrated intensely hypermetabolic disease in the base and shaft of penis that on fused CT localized to the ulcer in the penis [Figure 1]A. Disease was also noted involving external iliac and inguinal lymph nodes and additional lytic lesion in the left pubic symphysis [Figure 2]. The ulcerated lesion showing FDG uptake was confirmed to be metastatic from TCC. Patient was put on cisplatin and gemcitabine, given every 3 weeks for 6 cycles. Post-treatment PET/CT scan showed complete resolution of the metastatic activity [Figure 1]B.
Figure 1: F-18 FDG PET/CT maximum intensity projection image. (a) Intense uptake in the base and shaft of penis (arrow) and physiological uptake in neobladder (arrowhead). Two FDG avid lymph nodes, one left external iliac and one left inguinal, are also visualized. The post-therapy MIP image. (b) Complete resolution of the FDG uptake in the base and shaft of penis as well as in the lymph nodes

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Figure 2: Pre-therapy trans-axial PET/CT images. (a) Intense uptake in the periphery of necrotic left external iliac lymph node. Trans-axial CT image of the pelvis. (b) A lytic lesion in the left pubic symphysis while PET/CT image. (c) FDG uptake in lytic lesion as well as in a left inguinal lymph node

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Approximately 300 cases of penile metastases are reported worldwide. [1] Seventy percent of these metastases have their origin in the genitourinary tract, and the primary tumor is most frequently located in the bladder. [2] Various mechanisms by which lesions may metastasize to the penis have been reported. Bordeau et al. reported 3 cases of penile metastases from TCC of the bladder, in which they assumed that metastatic spread from primary bladder cancer to the penis occurred mainly via the retrograde venous route. [2] There are also a few reports of TCC seeding outside the urinary tract after iatrogenic procedures (i.e., partial cystectomy, suprapubic cystostomy, pyelotomy, and laparoscopy) as the cause of cutaneous metastasis. [3],[4],[5],[6]

The utility of FDG-PET in the evaluation of bladder cancer seems to be limited to the evaluation of distant metastases. [7],[8] This may be due to the fact that interpretation of F-18 FDG PET images is difficult because of urinary excretion of this radiotracer, which accumulates in the kidneys, ureters, and bladder and may conceal or mask pathologic deposits in malignant lesions. Bachor et al. [9] in their study using F-18 FDG PET for pre-operative staging of bladder cancer in 64 patients reported a sensitivity of 67%, specificity of 86%, and diagnostic accuracy of 80% in regional or lymph node staging and found these to be superior to those obtained with conventional imaging methods. Similarly, Kosuda et al. [10] analyzed the contribution of F-18 FDG PET in assessment of the residual or recurrent primary tumor, regional lymph node involvement, and metastasis detection in histologically confirmed residual or recurrent bladder cancer after surgery and/or radiotherapy. They reported that F-18 FDG PET imaging had excellent diagnostic performance in the detection of distant disease, since it correctly identified 100% distant metastatic lesions (lung, bone, and distant lymph node stations.) Recently, Jadvar et al. [11] reported that the information provided by PET-CT changed the management in 17% of their patients. To the best of our knowledge, this is the first reported case of penile metastasis from TCC of the urinary bladder post-cystectomy demonstrated by F-18 FDG PET and also associated solitary bone metastasis. Further response to chemotherapy using FDG PET/CT has also been elucidated in this report.

 
  References Top

1.
Akman Y, Cam K, Kavak A, Alper M. [F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma. Int J Urol 2003;10:103-7.  Back to cited text no. 1
    
2.
Bordeau KP, Lynch DF. Transitional cell carcinoma of the bladder metastatic to the penis. Urology 2004;63:981-3.  Back to cited text no. 2
    
3.
Miyamoto T, Ikehara A, Araki M, Akaeda T, Mihara M. Cutaneous metastatic carcinoma of the penis: Suspected metastasis implantation from a bladder tumor. J Urol 2000;163:1519.  Back to cited text no. 3
    
4.
Takahashi S, Ozono S, Cho M, Fujimoto K, Sasaki K, Hirao Y, et al. [Penile and urethral metastases from superficial bladder tumor after TUR: A case report]. Hinyokika Kiyo 1989;35:1055-9.  Back to cited text no. 4
    
5.
Berger AP, Rogatsch H, Hoeltl L, Steiner H, Bartsch G, Hobisch A. Late penile metastasis from primary bladder carcinoma. Urology 2003;62:145.  Back to cited text no. 5
    
6.
Maier U, Grimm M. Transitional cell carcinoma of the bladder with solitary metastasis to the penis 4 years after successful heart transplantation. A case report and review of the literature. Transplantation 1994;58:861-3.  Back to cited text no. 6
    
7.
Kumar R, Zhuang H, Alavi A. PET in the management of urologic malignancies. Radiol Clin North Am 2004;42:1141-53, ix.  Back to cited text no. 7
    
8.
Schöder H, Larson SM. Positron emission tomography for prostate, bladder, and renal cancer. Semin Nucl Med 2004;34:274-92.  Back to cited text no. 8
    
9.
Bachor R, Kotzerke J, Reske SN, Hautmann R. [Lymph node staging of bladder neck carcinoma with positron emission tomography]. Urologe A 1999;38:46-50.  Back to cited text no. 9
    
10.
Kosuda S, Kison PV, Greenough R, Grossman HB, Wahl RL. Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer. Eur J Nucl Med 1997;24:615-20.  Back to cited text no. 10
    
11.
Jadvar H, Quan V, Henderson RW, Conti PS. [F-18] Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma. Int J Clin Oncol 2008;13:42-7.  Back to cited text no. 11
    


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