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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 51  |  Issue : 4  |  Page : 447-449

Pattern of bloodstream infections in patients with hematological malignancies in a tertiary care centre


1 Department of Pediatric Oncology, Asian Insititute of Oncology, SL Raheja Hospital, Mahim, Mumbai, Maharashtra, India
2 Department of Medical Oncology, Asian Insititute of Oncology, SL Raheja Hospital, Mahim, Mumbai, Maharashtra, India

Correspondence Address:
S Bansal
Department of Pediatric Oncology, Asian Insititute of Oncology, SL Raheja Hospital, Mahim, Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.175308

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Background: The purpose of our study was to evaluate the clinical characteristics, to understand the pattern of bloodstream infections (BSIs), and to determine the risk factors contributing to high-risk febrile neutropenia in patients with hematological malignancy. Materials And Methods: A comprehensive review of retrospective data was done from 2004 till 2012 from a single center. Results: There were total 171 consecutive febrile episodes with 103 acute lymphoblastic leukemia (ALL) patients and 63 acute myeloid leukemia (AML) patients. The highest number of febrile neutropenia episodes occurred during ALL and AML induction followed by consolidation treatment with high-dose cytarabine. In our study population, the most common organisms isolated were Gram-positive (20%) followed by Gram-negative (6.4%) organisms. The incidence of fungal sepsis was only 3%. In our study, it was seen that the recovery from febrile neutropenia depends upon the disease, ALL recovered rapidly compared to AML (P < 0.001) and also the on the phase of treatment, i.e consolidation recovered earlier than induction (P < 0.001). There was no death recorded in this study population during febrile neutropenia. Conclusions: The incidence of febrile neutropenia depends upon the type of haematological malignancy and the aggressiveness of therapy required treating the disease especially during induction. The improvement in antimicrobial coverage and its prompt use leads to the selective growth of Gram-positive organisms.






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