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 » Introduction
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  Table of Contents  
REVIEW ARTICLE
Year : 2015  |  Volume : 52  |  Issue : 1  |  Page : 94-97
 

Developing a comprehensive cancer specific geriatric assessment tool


Department of Palliative Medicine, Tata Memorial Hospital, Mumbai, Maharashtra, India

Date of Web Publication3-Feb-2016

Correspondence Address:
N Salins
Department of Palliative Medicine, Tata Memorial Hospital, Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.175588

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 » Abstract 

Background: Population aging is one of the most distinctive demographic events of this century. United Nations projections suggest that the number of older persons is expected to increase by more than double from 841 million in 2013 to >2 billion by 2050. It is estimated that 60% of the elderly patients may be affected by cancer and may present in the advanced stage. The aim of this paper was to develop a brief cancer-specific comprehensive geriatric assessment tool for use in a geriatric population with advanced cancer that would identify the various medical, psychosocial, and functional issues in the older person.Methods: Literature on assessment of geriatric needs in an oncology setting was reviewed such that validated tools on specific domains were identified and utilized. The domains addressed were socioeconomic, physical symptoms, comorbidity, functional status, psychological status, social support, cognition, nutritional status and spiritual issues. Validated tools identified were Kuppuswamy scale (socioeconomic), Edmonton Symptom Assessment Scale (Physical symptoms) and SAKK cancer-specific geriatric assessment tool, which included six standard geriatric measures covering five geriatric domains (comorbidity, functional status, psychological status, social support, cognition, nutritional status). The individual measures were brief, reliable, and valid and could be administered by the interviewer.Conclusion: The tool was developed for use under the geriatric palliative care project of the department of palliative medicine at Tata Memorial Hospital, Mumbai. We plan to test the feasibility of the tool in our palliative care set-up, conduct a needs assessment study and based on the needs assessment outcome institute a comprehensive geriatric palliative care project and reassess outcomes.


Keywords: Advanced cancer, geriatric assessment tool, palliative care


How to cite this article:
Rao S, Salins N, Deodhar J, Muckaden M. Developing a comprehensive cancer specific geriatric assessment tool. Indian J Cancer 2015;52:94-7

How to cite this URL:
Rao S, Salins N, Deodhar J, Muckaden M. Developing a comprehensive cancer specific geriatric assessment tool. Indian J Cancer [serial online] 2015 [cited 2019 Aug 24];52:94-7. Available from: http://www.indianjcancer.com/text.asp?2015/52/1/94/175588



 » Introduction Top


United Nations projections suggest that the number of older persons is expected to increase by more than double from 841 million in 2013 to >2 billion by 2050. India has about 100 million elderly at present, and this is expected to increase to 324 million by 2050, constituting 20% of the total population.[1] Cancer is 11 times more likely to develop in people over 65 years as compared to their younger counterparts.[2] In the United States, 60% of all cancers and approximately 70% of cancer-related deaths [3] occur in those 65 years or older. Based on an Indian Council of Medical Research population-based cancer registry report the prevalence of cancer patients in India above the age of 60 is estimated to reach >1 million by 2021.[4] Government of India adopted the “National Policy on Older Persons” in January 1999 defining senior citizen or elderly as a person who is of age 60 or above. Thus for the purpose of this paper the age 60 years or above will be considered as elderly.

Elderly patients needing palliative care services present with unique concerns and the traditional assessment and management guidelines fail to address their complex needs. The aim of this paper was to develop a brief cancer-specific comprehensive geriatric assessment tool for use in geriatric population in an advanced cancer care set-up that would identify the various medical, psychosocial, and functional issues in the older person.


 » Background and Rationale Top


Review of literature in geriatrics and oncology indicate that the elderly patients have multiple issues involving various domains that is, physical, cognitive, affective, social, financial, environmental and spiritual that affect their global health.

Pain occurs in nearly all patients with advanced cancer [5] and is twofold higher in those over the age of 60 or above.[6],[7] Elderly patients in addition have chronic nonmalignant pain that predate cancer. Expression of pain in the elderly patients may be atypical and presence of cognitive impairment, delirium and dementia create barriers in effective pain assessment.[8] Misconceptions about cancer and aging process as well as cultural aversion to narcotics, concerns about side effects and fear of addiction to opioids [9] further impede effective pain management. Besides pain, a high prevalence of symptoms such as fatigue (up to 70% of elderly patients),[10] loss of appetite and depression has been reported in elderly patients with advanced cancer. Unrelieved or sub-optimally treated symptoms have a serious effect on the quality of life of the elderly [11] resulting in depression, social isolation, and immobility.[12] The elderly population have multiple comorbidities that affect the outcomes in patients with cancer [13],[14] and in Indian elderly population an added burden of communicable diseases compound this problem.[15] In addition, the elderly patients are at an increased risk of drug-drug and drug-disease interactions.[16] Frailty,[17] functional status [18] and malnutrition [19] are crucial factors that need to be taken into consideration in the care of older adults as it is a strong predictor of negative outcomes including disability, institutionalization, and mortality. A study conducted in a tertiary care hospital in India identified poor nutritional status among elderly cancer patients.[20] The prevalence of depression in cancer ranges from 17% to 25%[21] and has been correlated with decreased quality of life and is a significant predictor of mortality.[22] Suicide is another major concern in older adults almost twice as likely as the younger populations.[23] Cognitive impairments, delirium and dementia have been identified as independent prognostic indicators of survival [24] in patients with cancer. Lower socioeconomic status has an adverse effect on survival due its effect on nutrition, social support, and lack of access to better disease modifying options. In India problems of the elderly patients are further compounded by factors like lack of social security and inadequate facilities for health care, rehabilitation, and recreation.[25] Major proportion of the elderly patients are out of workforce and partially or totally dependent on others.[26] Social isolation is also an independent predictor of mortality in the geriatric population.[27]

An audit conducted as part of a geriatric palliative care project over 6 months (October 2013–March 2014) by the Department of Palliative Medicine, Tata Memorial Hospital, India indicate that nearly 40% of all patients with advanced cancer referred to palliative care services were aged 60 years or above. The most common physical symptoms reported were pain (74%), fatigue (90%), loss of appetite (75%) and anxiety (45%) as reported on the Edmonton Symptom Assessment Scale. About 68% of the elderly patients complained of mobility impairment with 58% having an Eastern Cooperative Oncology Group-Performance Status of 2 or 3. However, no details regarding patient's baseline level of functioning that is, ability to complete Activities of Daily Living (ADLs) and instrumental activities of daily living (IADLs) were available. Cognitive impairment, perceived social support, presence of psychological and spiritual concerns, nutritional status were not being assessed adequately in a busy palliative care outpatient set-up highlighting the need for a comprehensive geriatric assessment.

A meta-analysis of 28 controlled trials of comprehensive geriatric assessment demonstrated that geriatric assessments if linked with geriatric interventions reduce re-hospitalizations and mortality in older patients through early identification and treatment of problems,[28] reduce functional decline and improve mental health outcomes.[29] However, these tools are time-consuming and impractical for use in a busy palliative care setting.[30] Our goal was to develop a brief and comprehensive assessment tool that could be used in the geriatric population in an advanced cancer care and palliative care setting, which would include all the essential domains evaluated by geriatricians and oncologists as independent predictors of mortality and morbidity in older patients. Following are the validated tools used in of the geriatric population addressing the above-mentioned domains.


 » Measurements Top


Modified Kuppuswamy's Socioeconomic Status Scale (2013)

Kuppuswamy's scale is widely used to measure the socioeconomic status of an individual in an urban Indian community based on three variables namely education level of head of family (HOF), occupation of HOF and income per month. It is an important tool in hospital and community-based research in India, which was originally proposed in 1976. Socioeconomic status on this study was scored using the updated version of the scale.[40]

Edmonton symptom assessment system

This tool is designed to assist in the assessment of nine symptoms common in cancer patients: Pain, tiredness, nausea, loss of appetite, shortness of breath, drowsiness, depression, anxiety, best wellbeing and others. It is the patient's opinion of the severity of the symptom and the gold standard for symptom assessment.

Charlson comorbidity index

Charlson comorbidity index (CCI) assesses comorbidity level by taking into account both the number and severity of 19 pre-defined comorbid conditions. The CCI was further adapted to account for increasing age by adding one point to the CCI score for each decade of life over the age of 50. Hall (William H Hall, 2004) et al. have created a Microsoft Excel Macro to calculate CCI to facilitate its correct and uniform use in medical research that was used to assess comorbidity in this study. Has good reliability, excellent correlation with mortality and progression-free survival outcomes, and is easily modifiable particularly to account for the effect of age.[41]

Vulnerable elders survey-13

Vulnerable elders survey (VES-13) is a validated tool used to assess the risk of health deterioration in community-dwelling older adults by considering a number of factors including disabilities, age, self-reported health status, and functional limitations. The VES-13 correlates with the Comprehensive Geriatric Assessment with a value of 0.4 and with ADL/IADL scales with a value of 0.5 showing it as a valid tool. Internal consistency for the VES-13 in a study by Luciani et al. found a Cronbach's alpha of 0.9 when compared against Comprehensive Geriatric Assessment (CGA). Sensitivity was reported to be 87% and specificity of 62% versus CGA and 90% and 70% versus ADL/IADL.
Table 1: Cancer-specific geriatric assessment tool

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Number of falls in the last 6 months

Older patients are at a risk of falls due to mobility, balance, and gait impairments. Patients with cancer are at a greater risk for pathologic fracture or hemorrhage.

Geriatric depression scale-5

The Geriatric depression scale (GDS) was specifically developed for use with older people, 60 years and above, as a basic screening measure for depression. Holy and colleagues selected 5 items that had the strongest correlation with a clinical diagnosis of depression and developed the GDS-5 for use in faster paced settings. Sensitivity of GDS-5 ranges from 89% to 98% and specificity ranges from 73% to 85% (Rinaldi et al. 2003; Weeks et al. 2003). Reliability coefficient was 0.84, and interrater reliability was 0.88 (Rinaldi et al. 2003).

The Modified Medical Outcomes Study Social Support Survey

To reduce respondent burden the original 19-item Medical Outcomes Study Social Support Survey [42] was shorted to an 8-item version named modified Medical Outcomes Study Social Support Survey (mMOS-SS).[43],[44] The mMOS-SS has two subscales covering two domains (emotional and instrumental (tangible) social support). Moser et al. demonstrated that the mMOS-SS demonstrated good internal reliability, consistent factor structure, good convergent, divergent and discriminate validity. It's a reliable and valid tool to measure social support especially in the geriatric context.

The Mini-Cog

This is a simple screening tool developed in 2000 to detect cognitive impairment quickly in older adults. It comprises of 3-item recall test and clock drawing test, which allows clinicians to quickly assess numerous cognitive domains and provides a visible record of both normal and impaired performance that can be tracked over time. In the original validation article, with a sample of culturally diverse, community-dwelling persons, 50% of whom had dementia, the Mini-Cog demonstrated a sensitivity of 99% and specificity of 96%, compared with Mini Mental State Examination (91% and 92% respectively).[45] A score of 3–5 out of 5 is a negative screen for dementia (Borson et al., 2006), but a score of 0–2 out of 5 may increase detection of mild cognitive impairment (McCarten et al., 2012). The Mini-Cog is not strongly influenced by education, culture, or language, and it was perceived as less stressful to the patient than other longer mental status tests.

Mini-Nutritional assessment Short Form

The Mini-Nutritional assessment (MNA) - Short Form is a quick screening version of the original MNA used to identify older adults at risk for malnourishment early so that nutritional intervention can be initiated. The sensitivity has been reported as 97.9% and specificity 100% for predicting under-nutrition, diagnostic accuracy 98.7%, reliability not reported.

Spiritual status

We screened the spiritual concerns using the two-question model developed by Fitchett and Risk. The two questions included:

  • Is spirituality or religion important to you
  • Are your spiritual resources working for you?



 » Conclusion Top


Geriatric patients with advanced cancer present with a unique set of needs and challenges and the prevailing adult palliative care needs assessment model fails to recognize these distinctive domains. Any assessment that does not address the special needs of the elderly would be incomplete and inappropriate. An effective geriatric palliative care program should evaluate the physiologic, functional, and health-related quality of life of the patient; aid in formulating appropriate treatment and management strategies; monitor the clinical and functional outcomes; and in addition aid in identifying patient and caregiver treatment preferences.

Department of Palliative Medicine at Tata Memorial Hospital, Mumbai, developed this tool, as an attempt to bridge gaps in needs assessment such that it will positively improve geriatric palliative care services and thereby improve outcomes. We plan to assess the feasibility of the tool, validate it in regional language, conduct a needs assessment study, and based on the needs assessment outcomes, institute a comprehensive geriatric palliative care package and reassess outcomes of intervention.

 
 » References Top

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