Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :750
Small font sizeDefault font sizeIncrease font size
Navigate here
  Search
 
  
Resource links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (369 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   References
   Article Figures

 Article Access Statistics
    Viewed1108    
    Printed38    
    Emailed0    
    PDF Downloaded161    
    Comments [Add]    

Recommend this journal

 

  Table of Contents  
LETTER TO THE EDITOR
Year : 2015  |  Volume : 52  |  Issue : 4  |  Page : 589
 

Aggressive angiomyxoma perineum: A rare soft tissue neoplasm in males


1 Division of Medical Oncology, SMS Medical College and Hospital, Jaipur, Rajasthan, India
2 Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India

Date of Web Publication10-Mar-2016

Correspondence Address:
H Malhotra
Division of Medical Oncology, SMS Medical College and Hospital, Jaipur, Rajasthan
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.178398

Rights and Permissions



How to cite this article:
Mathur A, Yadav A, Jasuja S, Jindal A, Malhotra H. Aggressive angiomyxoma perineum: A rare soft tissue neoplasm in males. Indian J Cancer 2015;52:589

How to cite this URL:
Mathur A, Yadav A, Jasuja S, Jindal A, Malhotra H. Aggressive angiomyxoma perineum: A rare soft tissue neoplasm in males. Indian J Cancer [serial online] 2015 [cited 2019 Dec 9];52:589. Available from: http://www.indianjcancer.com/text.asp?2015/52/4/589/178398


Sir,

Aggressive angiomyxoma (AA) is a rare mesenchymal tumor of pelvic-perineal region with female:male ratio of 6:1[1] and only around 40 cases being reported in males.

A 30-year-old male presented with 1–2 years history of gradually increasing perineal swelling with no other significant family, the past, or personal history. On examination, bilateral (B/L) testis was normal; right hydrocele was present, and the most significant finding was of 6 cm × 4 cm mass in perineum. A ultrasonography-guided fine needle aspiration cytology done was inconclusive, and further wide excision of mass lesion was done. Histopathological examination gave an overall impression of AA of the perineal tissues [Figure 1]. Eighty percent of tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PR) with score 3 intensity. The patient was thus diagnosed as having AA perineum. Post-wide excision patient was started on gonadotropin-releasing hormone (GnRH) agonist (goserelin) and tamoxifen and has responded well [Figure 2].
Figure 1: Microphotographs showing aggressive angiomyxoma of perineum with dilated and congested vessels with areas of fresh hemorrhage in a hypocellular myxoid background

Click here to view
Figure 2: Pre- and post-chemotherapy computed tomography scan of our patient with aggressive angiomyxoma perineum showing significant reduction in the size of tumor (H and E, ×50)

Click here to view


AA is a benign tumor but still termed aggressive due to its tendency to recur after surgical excision. Clinically, it presents as a soft tissue mass. Our patient also presented with a slow growing mass in perineum. In general, the diagnosis is made by histopathological examination alone and immunohistochemistry is seldom required. Genetics show HMGA2 rearrangement. Radical surgery with wide margins is the treatment of choice and GnRH agonists have been used successfully specifically in ER PR positive AAs. In our patient, GnRH agonist (goserelin) was used with good effect. Prognosis is good with a propensity to recur hence long-term follow-up is warranted.

 
  References Top

1.
Mathieson A, Chandrakanth S, Yousef G, Wadden P. Aggressive angiomyxoma of the pelvis: A case report. Can J Surg 2007;50:228-9.  Back to cited text no. 1
    


    Figures

  [Figure 1], [Figure 2]



 

Top
Print this article  Email this article
 

    

  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow