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 ORIGINAL ARTICLE
Year : 2015  |  Volume : 52  |  Issue : 7  |  Page : 153-157

Prognostic role of s-phase kinase-associated protein 2 in breast cancer: A meta-analysis


1 Department of Breast thyroid, The Second Hospital of Jilin University, Jilin, China
2 Department of Outpatient, Changchun Obstetrics Gynecology Hospital, Jilin, China
3 Department of General Surgery, The Second Hospital of Jilin University, Jilin, China
4 Department of Nursing, The Second Hospital of Jilin University, Jilin, China
5 Department of Orthopedics, The Second Hospital of Jilin University, Jilin, China
6 Department of Rheumatology and Immunology, The First Affiliated Hospital of Jilin University, Jilin, China
7 Department of Breast, The Second Hospital of Jilin University, China

Correspondence Address:
D Wang
Department of Breast, The Second Hospital of Jilin University
China
S Ma
Department of Rheumatology and Immunology, The First Affiliated Hospital of Jilin University, Jilin
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.186559

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OBJECTIVE: Emerging evidence has shown that the F-box protein S-phase kinase-associated protein 2 (Skp2) plays an important role in the pathogenesis of breast cancer (BC). Our study aimed to evaluate the prognostic value of Skp2 in BC patients using meta-analysis based on the published studies. MATERIALS AND METHODS: Eligible studies were identified by searching the online databases such as PubMed, EMBASE, and Web of Science up to October 2015. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to clarify the correlation between Skp2 expression and indicators of BC clinical outcomes, including overall survival (OS), disease-free survival (DFS), and BC-specific survival. RESULTS: In total, nine studies with 1820 BC patients were included for final analysis. The meta-analysis suggested that Skp2 overexpression was associated with poor OS (HR = 2.58, 95% CI: 1.83-3.63, P = 0.000) and poor DFS (HR = 2.12, 95% CI: 1.48-3.05, P = 0.000) in BC patients. CONCLUSIONS: This meta-analysis indicates that enhanced Skp2 is an independent prognostic factor for poor cancer survival.






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