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  Table of Contents  
ORIGINAL ARTICLE
Year : 2016  |  Volume : 53  |  Issue : 3  |  Page : 363-365
 

The pattern of invasive lobular carcinoma in the patients diagnosed with breast cancer from Balochistan


1 Department of Livestock Management, Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Balochistan, Pakistan
2 Department of Biotechnology, Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
3 Center for Nuclear Medicine and Radiotherapy (CENAR), Quetta, Pakistan
4 Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan

Date of Web Publication24-Feb-2017

Correspondence Address:
AH Baloch
Department of Livestock Management, Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Balochistan
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.200672

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 » Abstract 

Introduction: Invasive lobular carcinoma (ILC) is the second most common type of breast cancer accounting for 5%–15% of all the breast cancer cases. The present study was performed on 171 breast cancer patients from Balochistan registered in CENAR (Center for Nuclear Medicine and Radiotherapy), Quetta. Materials and Methods: Written consent was obtained from the patients. The history of the disease was taken from the patients, and the patients' enrollment files were retrieved. Results: Of the 171 patients, 5 (2.96%) were diagnosed with ILC with tumor Grade II, and stage of the cancer reported was Grade III in all the 5 patients affected with ILC. Conclusion: ILC is the second most common type of breast cancer diagnosed with comparatively lower grade but almost reported infiltrating.


Keywords: Balochistan, breast, carcinoma, infiltrating, invasive lobular carcinoma, lobular


How to cite this article:
Baloch A, Khosa A, Bangulzai N, Sadia H, Ahmed M, Khan F, Jan M, Tareen M, Kakar M, Shuja J, Naseeb H, Ahmad J. The pattern of invasive lobular carcinoma in the patients diagnosed with breast cancer from Balochistan. Indian J Cancer 2016;53:363-5

How to cite this URL:
Baloch A, Khosa A, Bangulzai N, Sadia H, Ahmed M, Khan F, Jan M, Tareen M, Kakar M, Shuja J, Naseeb H, Ahmad J. The pattern of invasive lobular carcinoma in the patients diagnosed with breast cancer from Balochistan. Indian J Cancer [serial online] 2016 [cited 2017 Sep 20];53:363-5. Available from: http://www.indianjcancer.com/text.asp?2016/53/3/363/200672



 » Introduction Top


Breast cancer is the most commonly diagnosed cancer among women worldwide,[1] and it is a diverse disease classified into various clinical types and subtypes based on histological, biological, and pathological features, clinical appearance, and behavior of the disease.[2],[3]

Invasive lobular carcinoma (ILC), also referred as infiltrating lobular carcinoma, affects the milk-producing glands, the lobules of the breast tissue, with the capacity of metastasizing to the other parts of the body. It is the second most common type of breast cancer after invasive ductal carcinoma (IDC) accounting for 5%–15% of all the breast cancer cases.[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14] The cases of ILC are considered to be diagnosed comparatively with a lower grade, with almost good prognosis, and estrogen receptors-positive, but almost found infiltrating.[15],[16],[17] ILCs cannot be easily palpated and captured mammographically with a diverse pattern of metastasis.[18],[19] ILCs are classified as pleomorphic, classic, Signet ring cells (malignant cells with large vacuoles) alveolar carcinoma, tubule-lobular, and solid subtypes.[20] Variations in the characteristics are associated with the patients' population and different diagnostic methods.[7],[8],[21]

The present study was performed on 171 breast cancer patients, >95% patients were diagnosed with IDC and 2.96% patients were diagnosed with ILC. Our objective in the current study was to investigate the occurrence and diverse pattern of ILC in the region.


 » Materials and Methods Top


The current study was performed on 171 breast cancer patients from different areas of Balochistan registered in CENAR (Center for Nuclear Medicine and Radiotherapy), Quetta, for treatment. After agreement with the patients taking part in the study as volunteers, a written consent was obtained from all the patients.

The patients were interviewed about the history of the disease; the questions asked to the patients were about the ethnicity, marital status, fertility, pregnancy history, occurrence/onset of the disease, age at the onset of the disease, date of diagnosis, family history, dietary pattern and smoking history, and exposure to X-rays before the onset of the disease.

The files of the patients were retrieved and the clinical/diagnosed reports were recorded from the files. Age and body mass index (BMI) of the patients were also recorded.


 » Results Top


Of the 171 breast cancer patients, 5 (2.96%) were diagnosed with ILC, 162 patients (95.86%) were diagnosed with IDC, whereas the other cases reported were 2 male patients diagnosed with breast cancer (primary lymphoma of breast), and 2 patients were reported to be diagnosed with ductal carcinoma in situ. Ethnicity of the patients included two patients were from Punjabi ethnic group and one from each Pashtun, Hazara, and Sindhi ethnic groups diagnosed with ILC of breast. BMI of the patients was also recorded, three patients were reported overweight and two patients were with normal BMI. The mean age of the patients was 49.6 years diagnosed with ILC, whereas three patients were diagnosed with ILC at postmenopausal age and two were diagnosed at premenopausal age. Out of the five cases of ILC, three patients were estrogen receptor and progesterone receptor (ERPR)-positive. All the five cases of ILC were diagnosed with tumor Grade II and the stage of the cancer was reported Grade III. Left breast tissue was affected in three patients and the right breast tissue was affected in two patients. Metastasis to the lymph nodes in all the five cases was high; the mean number of lymph nodes involved by tumor was 8.9. Dermis of the areola and nipple was involved in two breast cancer cases, whereas in one of the two cases, the pagetoid spread was also observed. Perinodal extension was reported in all the five cases.


 » Discussion Top


ILC is quite a diverse form of breast cancer affecting the milk-producing glands (lobules) of the breast tissue.[22] The metastatic pattern of ILC is almost similar to that of IDC; however, it is considered to spread unusual sites most commonly.[23],[24]

The present study was performed to figure out the diverse pattern and prevalence of ILC. In the current study, we investigated the cases of ILC among the patients of breast cancer from different areas of Balochistan registered in the CENAR for chemo- and radio-therapies. ILC accounts for 5%–10%[25] of all the breast cancer cases preceded by IDC that comprised 85%–95% of the breast cancer cases. In the current study, we identified 5 patients with ILC (2.96%) of all the breast cancer cases registered in CENAR during the period of current study was performed. Studies conducted in different areas of Pakistan proposing the cases of ILC 7%,[26] 2%,[27] and 2.98%,[14] whereas the statistics from other part of the world suggest that 5-10% of all the breast cancer cases are reported as ILC.[25],[28] Incidences of ILC are most often reported to occur in postmenopausal age.[13],[29],[30],[31],[32] In the present study, out of five cases, three patients were diagnosed at postmenopausal age, and the mean age of all patients with ILC was 49.6. ILC cases are reported to be positive with estrogen and progesterone receptors-positive and almost found infiltrating.[15],[16],[17],[33],[34],[35] The current study revealed three cases with ERPR positive, and lymph node invasion was found in all the five cases with a mean of 8.9 of lymph nodes invaded by tumor.


 » Conclusion Top


ILC is the second most common type of breast cancer affecting the lobules of the breast tissue and is a polycentric malignancy affecting the breast tissue with diverse pattern of invasion to other parts of the body.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
 » References Top

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