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Year : 2017  |  Volume : 54  |  Issue : 5  |  Page : 25-30

Liquid biopsy: A potential and promising diagnostic tool for advanced stage non-small cell lung cancer patients


1 Senior Consultant Director of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
2 Surgical Oncologist, Asian Cancer Institute, Mumbai, India
3 Senior Consultant, Medical Oncology, Fortis Hospital, Mulund, Mumbai, India
4 Associate Professor in Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore and Consultant Medical Oncologist HCG Hospitals, Bangalore, India
5 Professor, Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
6 Director & Head, Department of Oncology & Hematology, Artemis Health Institute, Gurgaon, Haryana, India
7 Senior Consultant, Department of Oncology, Apollo Health City, Apollo Hospitals, Hyderabad, India
8 Consultant Oncologist, Dinanath Mangeshkar Hospital, Pune, India
9 Consultant Molecular Pathologist, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India

Correspondence Address:
Dr. D C Doval
Senior Consultant Director of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijc.IJC_514_17

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More than 50% of non-small cell lung cancer (NSCLC) cases harbor an actionable mutation, and molecular testing at different intervals can help in personalized and targeted treatment. Core tissue biopsy and needle biopsy done at the time of diagnosis/disease progression are interventional, time-consuming and can affect the patients adversely. Noninterventional biomarker testing by liquid biopsy promises to revolutionize advanced stage cancer screening. The present report was formulated based on an expert panel meeting of renowned oncologists who gave their opinions for minimally invasive liquid biopsy to detect targetable molecular biomarkers in advanced NSCLC cases. An exhaustive literature search was done to support their recommendations. Clinical utility of minimally invasive liquid biopsy, for detection of molecular biomarkers in advanced stage NSCLC patients, was broadly discussed by the key opinion leaders.






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