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  Table of Contents  
LETTERS TO THE EDITOR
Year : 2018  |  Volume : 55  |  Issue : 3  |  Page : 306-307
 

Primary borderline mucinous cystadenoma of the mesentery


Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication28-Jan-2019

Correspondence Address:
Dr. Manoj Gopal Madakshira
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijc.IJC_225_18

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How to cite this article:
Madakshira MG, Saikia UN. Primary borderline mucinous cystadenoma of the mesentery. Indian J Cancer 2018;55:306-7

How to cite this URL:
Madakshira MG, Saikia UN. Primary borderline mucinous cystadenoma of the mesentery. Indian J Cancer [serial online] 2018 [cited 2019 Jul 19];55:306-7. Available from: http://www.indianjcancer.com/text.asp?2018/55/3/306/250884




Mesenteric cysts are rare lesions with an estimated incidence of 1:27,000.[1] They can be either pseudocysts or epithelial cysts. The epithelial cysts can be classified as mesothelial, urachal, lymphatic, enteric, or Mullerian phenotypes.[2] The Mullerian phenotype epithelial cysts can be of serous and mucinous subtypes. Both of which are thought to arise from Mullerian remnants in the retroperitoneum.[1],[2] These cysts are usually asymptomatic and usually present as a large abdominal mass. Rarely these cysts can present acutely as a result of rupture, torsion, or intestinal obstruction.[3] We discuss a rare case of borderline mucinous cystadenoma in a 42-year-old male.

A 44-years-old male patient presented with complains of distended abdomen and uneasiness. On examination, a firm mass was felt occupying the lower half of the abdomen reaching 2 cm above the umbilicus. A computed tomography showed a solid cystic lesion arising from the mesentery measuring 18 × 15 × 10 cm, adherent to the dome of the urinary bladder with fat planes present between the other abdominal organs including pancreas, stomach, and intestine [Figure 1]a and [Figure 1]b. Following an exploratory laparotomy, the mass was excised. The gross examination revealed an irregular mass with a smooth outer surface and firm consistency. The cut surface showed a multilocular cyst enclosing mucinous material [Figure 1]c. Histopathological examination showed multiple cysts of varying caliber lined by cuboidal to tall columnar epithelium having basally placed nuclei and vacuolated mucin-filled cytoplasm [Figure 1]d and [Figure 1]e. At places the epithelium showed papillary projections with nuclear stratification. The underlying stroma was composed of spindle cells with oval hyperchromatic nuclei and minimal amphophilic cytoplasmic processes, resembling ovarian stroma. No definitive evidence of invasion was seen. Immunohistochemistry showed the epithelial cells to be positive for CK7 (diffuse and cytoplasmic) and CEA (diffuse and cytoplasmic) while being negative for CK20, calretinin, and GATA3. The stromal cells were uniformly positive for ER and PR (diffuse and nuclear) [Figure 2]. A diagnosis of borderline mucinous cystadenoma of mesentery was made with an advice for close follow up. The patient was asymptomatic and free of tumor at the end of 6 months of follow-up.
Figure 1:(a) Computed tomography anterior–posterior view of the tumor showing the heterogeneous cystic nature. (b) Computed tomography lateral view of the tumor showing the relation of the tumor with the kidneys, loops of intestine, and liver. (c) Cut surface of the tumor showing the multilocular appearance. (d) H and E, section (×100) showing cysts of varying sizes. (e) H and E, section (×400) showing columnar cells with focal papillary arrangement and stratification

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Figure 2: (a) Immunohistochemistry for ER being positive in the stromal cells. (b) Immunohistochemistry for CK7 being positive in the epithelial cells. (c) Immunohistochemistry for carcinoembryonic antigen being positive in the epithelial cells. (d) Immunohistochemistry for CK20 being negative in the epithelial cells

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Mucinous cystadenomas of mesentery are rare lesions. The accepted hypothesis explaining the pathogenesis of these lesions is the possible neoplastic proliferation of the Mullerian cells which may remain along the course of the Mullerian duct.[3],[4] Similar to the ovarian tumor, mucinous cysts of mesentery are also graded as benign, borderline, and malignant neoplasms.[1] Immunohistochemistry is valuable to identify these neoplasms, with the epithelial cells having an immunophenotype of CK7 and CEA positivity and the stromal cells expressing ER and PR.[5] The differential diagnoses include other cystic lesions of mesentery which include pseudocysts and other epithelial cysts.[3] The pseudocysts usually have a preceding history of trauma and lack a lining epithelium. The phenotype of the epithelial cell can be ascertained by the cytomorphology of the cells and by resorting to immunohistochemistry.[3],[4] Pre-operative computed tomography helps to delineate the extent of the mass to help the surgeon plan appropriate resection planes.[1],[6] Incompletely excised and neoplasms which are borderline and beyond need a close follow up as recurrences are known.[6]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Metaxas G, Tangalos A, Pappa P, Papageorgiou I. Mucinous cystic neoplasms of the mesentery: A case report and review of the literature. World J Surg Oncol 2009;7:47.  Back to cited text no. 1
    
2.
Del Gobbo A, Bimbatti M, Ferrero S. A case report of mesenteric mucinous cystoadenoma with review of the literature. BMC Gastroenterol 2010;10:105.  Back to cited text no. 2
    
3.
Challa SR, Senapati D, Nulukurthi TK, Chinamilli J. Mucinous mesenteric cyst of the sigmoid mesocolon: A rare entity. BMJ Case Rep 2016;2016. pii: bcr2015210411.  Back to cited text no. 3
    
4.
Banerjee R, Gough J. Cystic mucinous tumours of the mesentery and retroperitoneum: Report of three cases. Histopathology 1988;12:527-32.  Back to cited text no. 4
    
5.
Dierickx I, Jacomen G, Schelfhout V, Moerman P, Corveleyn P, Spiessens T, et al. Primary retroperitoneal mucinous cystadenocarcinoma: A case report and review of the literature. Gynecol Obstet Invest 2010;70:186-91.  Back to cited text no. 5
    
6.
Cauchy F, Lefevre JH, Mourra N, Parc Y, Tiret E, Balladur P, et al. Mucinous cystadenoma of the mesocolon, a rare entity frequently presenting with features of malignity: Two case reports and review of the literature. Clin Res Hepatol Gastroenterol 2012;36:e12-6.  Back to cited text no. 6
    


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