| ORIGINAL ARTICLE
|Year : 2020 | Volume
| Issue : 1 | Page : 89-92
Chronic calculus cholecystitis: Is histopathology essential post-cholecystectomy?
Amul K Butti1, Shakti K Yadav1, Alekh Verma1, Abhijit Das1, Roshina Naeem1, Ratna Chopra2, Sompal Singh1, Namrata Sarin1
1 Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India
2 Department of Surgery, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India
Background: Carcinoma of the gall bladder (GB) is the most common malignancy of the gastrointestinal tract. One percent of cholecystectomy specimens show incidental gall bladder cancers (GBCs).
Aim: Our aim of the study to was evaluate the utility of routine histopathology of cholecystectomy specimens removed with a diagnosis of gall bladder diseases (GBD).
Materials and Methods: A retrospective study was done reviewing the histopathological records of 906 patients who underwent cholecystectomy. Demographic details, gross findings, and microscopic findings noted. All the cases were categorized into two groups, A and B. Group A included the cases with any gross abnormality including wall thickness ≥4 mm and group B included rest of the cases.
Results: Majority of the patients were in the age group of 31–40 years of age. Out of 906 patients studied, majority of them were females with F:M ratio of 6.14:1. Of the 47 cases which were included in group A (with macroscopic abnormality), six cases had gall bladder carcinoma on microscopy. One case from group B with macroscopically normal-appearing GB had invasive carcinoma on microscopy. In our study, we found a sensitivity of 85.71% and specificity of 95.44%, while positive predictive value (PPV) was 91.11% and negative predictive value (NPV) was 99.65% of macroscopic abnormality in the diagnosis of invasive carcinoma.
Conclusion: All cholecystectomy specimens must be examined by histopathologists who must decide whether processing for microscopy is needed. Microscopic examination may be reserved for the specimen with a macroscopic lesion. This will result in a reduction of costs and pathology workload without compromising patient management.
Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi
Source of Support: None, Conflict of Interest: None
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