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Year : 2011  |  Volume : 48  |  Issue : 1  |  Page : 94--98

Helicobacter pylori infection in relation to gastric cancer progression

A Venkateshwari1, D Krishnaveni1, S Venugopal1, P Shashikumar2, A Vidyasagar3, A Jyothy1 
1 Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad - 500 016, India
2 Sai Nikith Speciality Hospital and Laparoscopic Center, Kothapet, Hyderabad - 500 036, India
3 Department of Gastroenterology, Gandhi Hospital, Secunderabad - 500 003, India

Correspondence Address:
A Venkateshwari
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad - 500 016
India

Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.


How to cite this article:
Venkateshwari A, Krishnaveni D, Venugopal S, Shashikumar P, Vidyasagar A, Jyothy A. Helicobacter pylori infection in relation to gastric cancer progression.Indian J Cancer 2011;48:94-98


How to cite this URL:
Venkateshwari A, Krishnaveni D, Venugopal S, Shashikumar P, Vidyasagar A, Jyothy A. Helicobacter pylori infection in relation to gastric cancer progression. Indian J Cancer [serial online] 2011 [cited 2020 Aug 8 ];48:94-98
Available from: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2011;volume=48;issue=1;spage=94;epage=98;aulast=Venkateshwari;type=0