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Year : 2011  |  Volume : 48  |  Issue : 3  |  Page : 289--295

Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: A prospective longitudinal study

MS Tiwana1, MK Mahajan1, B Uppal2, G Koshy3, J Sachdeva1, HN Lee1, SD Talole4 
1 Department of Radiation Oncology, Christian Medical College and Hospital, Ludhiana, India
2 Department of Biochemistry, Christian Medical College and Hospital, Ludhiana, India
3 Department of Oral Pathology and Microbiology, Christian Medical College and Hospital, Ludhiana, India
4 Department of Medical Records, Biostatistics and Epidemiology, Tata Memorial Hospital, Parel, Mumbai, India

Correspondence Address:
M S Tiwana
Department of Radiation Oncology, Christian Medical College and Hospital, Ludhiana
India

Background: We investigated the physico-biochemical changes in saliva and its relation to quality of life (QOL) in head and neck cancer patients following conventional radiation therapy (RT). Materials and Methods: 53 consecutive head and neck cancer patients underwent conventional RT using telecobalt photons. We analyzed objective sialometry and sialochemical parameters of salivary gland function and a physician reported Oral Assessment Protocol to assess the patients«SQ» QOL during (baseline, 3 and 6 weeks) and post RT (3 and 6 months). Statistical analysis was done using SPSS software (version 15.0; SPSS, Inc., Chicago, IL, USA). Results: Stimulated salivary flow rates had shown a consistent decline during and in post-RT analysis (P < 0.001). A significant correlation was seen between mean salivary flow rates at 6 months post-RT and mean salivary electrolytes and amylase levels during the same period (P < 0.001). Mean global QOL scores had significantly worsened during RT and were still significantly poorer at 6 months than initial pre-RT levels (P < 0.001). Further, significant correlation was established between salivary pH values with global QOL scores at 6 months (P = 0.05). Conclusions: Radiation-induced hyposalivation invariably persists and correlates with poor global QOL scores seen during and following conventional RT. Post RT, there is a trend for biochemical reversal toward pre-irradiation levels suggesting a subsiding inflammation or a probable functional recovery.


How to cite this article:
Tiwana M S, Mahajan M K, Uppal B, Koshy G, Sachdeva J, Lee H N, Talole S D. Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: A prospective longitudinal study.Indian J Cancer 2011;48:289-295


How to cite this URL:
Tiwana M S, Mahajan M K, Uppal B, Koshy G, Sachdeva J, Lee H N, Talole S D. Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: A prospective longitudinal study. Indian J Cancer [serial online] 2011 [cited 2020 Jan 27 ];48:289-295
Available from: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2011;volume=48;issue=3;spage=289;epage=295;aulast=Tiwana;type=0