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Year : 2015  |  Volume : 52  |  Issue : 4  |  Page : 568--573

Therapy and progression – induced O6-methylguanine-DNA methyltransferase and mismatch repair alterations in recurrent glioblastoma multiforme

S Agarwal, V Suri, MC Sharma, C Sarkar 
 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
C Sarkar
Department of Pathology, All India Institute of Medical Sciences, New Delhi
India

Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemotherapeutic agent, is largely dependent on the methylation status of the promoter of the gene O6-methylguanine-DNA methyltransferase (MGMT) and the integrity of the mismatch repair (MMR) system. Changes in these regulatory mechanisms at the time of recurrence may influence response to therapy. Deciphering the molecular mechanisms of resistance to these drugs may in future lead to improvised patient management. In this article, we provide an update of the spectrum of molecular changes that occur in recurrent GBMs, and thus may have an impact on patient survival and treatment response. For review, electronic search for the keywords “Recurrent GBM”, “Recurrent GBM AND MGMT” “Recurrent glioma AND MGMT”, “Recurrent GBM AND MMR” and “Recurrent glioma AND MMR”, “Recurrent GBM AND MMR” and “Recurrent glioma AND MMR” was done on PubMed and relevant citations were screened including cross-references.


How to cite this article:
Agarwal S, Suri V, Sharma M C, Sarkar C. Therapy and progression – induced O6-methylguanine-DNA methyltransferase and mismatch repair alterations in recurrent glioblastoma multiforme.Indian J Cancer 2015;52:568-573


How to cite this URL:
Agarwal S, Suri V, Sharma M C, Sarkar C. Therapy and progression – induced O6-methylguanine-DNA methyltransferase and mismatch repair alterations in recurrent glioblastoma multiforme. Indian J Cancer [serial online] 2015 [cited 2020 Aug 3 ];52:568-573
Available from: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2015;volume=52;issue=4;spage=568;epage=573;aulast=Agarwal;type=0