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Year : 2017  |  Volume : 54  |  Issue : 3  |  Page : 547--549

Short-term efficacy and safety of apatinib in advanced squamous cell carcinoma of the lung

Xiaowu Li1, Lechao Le2, Liang Han1, Youwei Zhang1, Sanyuan Sun1 
1 Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 277100, China
2 Department of Neurology, Xuzhou Central Hospital, Xuzhou 277100, China

Correspondence Address:
Dr. Liang Han
Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 277100
China

OBJECTIVE: To evaluate the short-term efficacy and safety of apatinib alone or combined with chemotherapy in the treatment of advanced squamous cell lung cancer. METHODS: Forty patients with advanced squamous cell lung carcinoma were enrolled in this study, who were treated in Xuzhou Central Hospital from 2014 to 2015. All patients underwent first-line or more chemotherapy. Patients were administrated with apatinib 425 mg/day, alone or combined with chemotherapy. The short-term efficacy was evaluated according to the RECIST criteria. The main safety event was evaluated by CTC-AE criteria. RESULTS: Among all the 40 patients, partial response in 5 cases, stable disease in 24 cases, progressive disease in 11 cases, overall response rate in 12.5%, disease control rate in 72.5%, the median progression-free survival was 3.7 months. The main adverse events were leukopenia, fatigue, and hypertension. Most of the adverse events were grade I and II level. CONCLUSION: The use of apatinib alone or combined with chemotherapy in patients with advanced or metastatic squamous cell lung carcinoma demonstrates a high response rate, favorable tolerability profile.


How to cite this article:
Li X, Le L, Han L, Zhang Y, Sun S. Short-term efficacy and safety of apatinib in advanced squamous cell carcinoma of the lung.Indian J Cancer 2017;54:547-549


How to cite this URL:
Li X, Le L, Han L, Zhang Y, Sun S. Short-term efficacy and safety of apatinib in advanced squamous cell carcinoma of the lung. Indian J Cancer [serial online] 2017 [cited 2020 Sep 27 ];54:547-549
Available from: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2017;volume=54;issue=3;spage=547;epage=549;aulast=Li;type=0