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Year : 2018  |  Volume : 55  |  Issue : 1  |  Page : 45--49

Locally advanced cervical cancer: A study of 5-year outcomes

Supriya Chopra1, Meetakshi Gupta1, Ashwathy Mathew1, Umesh Mahantshetty1, Reena Engineer1, G Lavanya1, Sudeep Gupta2, Jaya Ghosh2, Meenakshi Thakur3, Kedar Deodhar4, Santosh Menon4, Bharat Rekhi4, Jyoti Bajpai2, Seema Gulia2, Amita Maheshwari5, Rajendra Kerkar5, TS Shylasree5, SK Shrivastava1 
1 Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
2 Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
3 Department of Radiology, Tata Memorial Centre, Mumbai, Maharashtra, India
4 Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India
5 Department of Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Supriya Chopra
Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra
India

Background: Cervical cancer is the second most common cancer among Indian women. This present retrospective study was conducted to report patient outcomes with locally advanced cervical cancer treated in the year 2010. Materials and Methods: Case records of cervical cancer patients registered from January 1, 2010, to December 31, 2010 were retrieved. A total of 1200 patients were registered, of which 583 received either definitive or adjuvant radiotherapy (RT). Of these, 345 patients who received complete treatment at our hospital were included for outcome analysis. Descriptive statistics were used to summarize patient- and treatment-related variables, and Kaplan–Meier analysis was performed for survival analysis. Results: The median age was 56 years (range: 33–90). Squamous carcinoma was the most common histology (91.4%) and the majority were FIGO Stage III (45.4%). Median follow-up of the cohort was 44 months (1–85 months). The 5-year disease-free survival (DFS) across stages was 50%. Most important predictor of DFS was FIGO staging (Stage II vs. Stage III: 62% vs. 45%) and use of concurrent chemoradiotherapy (CTRT) l (RT vs. CTRT: 32% vs. 57%, respectively). Patients aged >70 years had a significantly poor DFS at 5 years; however, did not have any effect on survival. Grade 3 or more late toxicity was seen in only 5% of the patients. Conclusion: Five-year DFS of 62% and 45% of Stage II and III patients treated under routine care represents comparable stage-matched results to the rest of the world, respectively.


How to cite this article:
Chopra S, Gupta M, Mathew A, Mahantshetty U, Engineer R, Lavanya G, Gupta S, Ghosh J, Thakur M, Deodhar K, Menon S, Rekhi B, Bajpai J, Gulia S, Maheshwari A, Kerkar R, Shylasree T S, Shrivastava S K. Locally advanced cervical cancer: A study of 5-year outcomes.Indian J Cancer 2018;55:45-49


How to cite this URL:
Chopra S, Gupta M, Mathew A, Mahantshetty U, Engineer R, Lavanya G, Gupta S, Ghosh J, Thakur M, Deodhar K, Menon S, Rekhi B, Bajpai J, Gulia S, Maheshwari A, Kerkar R, Shylasree T S, Shrivastava S K. Locally advanced cervical cancer: A study of 5-year outcomes. Indian J Cancer [serial online] 2018 [cited 2020 Aug 11 ];55:45-49
Available from: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2018;volume=55;issue=1;spage=45;epage=49;aulast=Chopra;type=0