Figure 1: Timeline of detection of involvement of various organ systems Skl - skeletal, Skn - skin, LN - lymph nodes, Spl - spleen, Pulm -pulmonary, CBC - complete blood counts, BM - bone marrow, Endo- endocrine system, CNS - central nervous system. “0”: At time of presentation to our center. Timeline earliest: Time of detection of organ system involvement prior to presentation in months. Timeline latest: Time of detection of organ system involvement after presentation in months. Timeline median: Median time of detection of organ system involvement with relation to time of presentation.