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Figure 2: Schematic diagram of the three main signaling intracellular pathways that mediate IGF-IR functions ERK, externally regulated kinase; IGF-1R, insulin like growth factor-1 receptor; IRS; insulin receptor substrate; mTOR, mammalian target of rapamycin; P13K, phosphoinositide-3 kinase; PTEN, phosphatase and tensin homolog; SGK, ribosomal protein S6 kinase

Figure 2: Schematic diagram of the three main signaling intracellular pathways that mediate IGF-IR functions ERK, externally regulated kinase; IGF-1R, insulin like growth factor-1 receptor; IRS; insulin receptor substrate; mTOR, mammalian target of rapamycin; P13K, phosphoinositide-3 kinase; PTEN, phosphatase and tensin homolog; SGK, ribosomal protein S6 kinase