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Figure 1 : Growth factor independence can lead to sustained signaling in pathways that control essential biological functions, such as growth, apoptosis, angiogenesis, invasion, and DNA damage repair. Signal transduction can be blocked by monoclonal antibodies (MAB) that target the extracellular domain of the receptor or by small molecule tyrosine kinase inhibitors (TKi) that interact with enzymatic activity in the intracellular part of the receptor

Figure 1 : Growth factor independence can lead to sustained signaling in pathways that control essential biological functions, such as growth, apoptosis, angiogenesis, invasion, and DNA damage repair. Signal transduction can be blocked by monoclonal antibodies (MAB) that target the extracellular domain of the receptor or by small molecule tyrosine kinase inhibitors (TKi) that interact with enzymatic activity in the intracellular part of the receptor