Indian J Pharm Close
 

Figure 4: Diagrammatic representation of the structural differences between three subfamilies of Smads. The MH1 domain is shown in blue and the MH2 domain in green. eX3, Unique exon 3 of Smad2; H2, α -helix H2; NLS, nuclear localization signal; NES, nuclear export signal; PY, proline-tyrosine motif; SAD, Smad activation domain; SSXS*, motif of R-Smads with phosphorylated serine residues (Moustakas et al ., 2001)

Figure 4: Diagrammatic representation of the structural differences between three subfamilies of Smads. The MH1 domain is shown in blue and the MH2 domain in green. eX3, Unique exon 3 of Smad2; H2, α -helix H2; NLS, nuclear localization signal; NES, nuclear export signal; PY, proline-tyrosine motif; SAD, Smad activation domain; SSXS*, motif of R-Smads with phosphorylated serine residues (Moustakas et al ., 2001)