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Figure 5: Smad-signaling centers. R-Smads (S) anchored to microtubules or filamin become mobilized toward SARA and the receptors where multiprotein centers are organized with the aid of scaffolding proteins containing PDZ domains, additional adaptors (Ad) and R-Smad and Smad4 (S4) anchors-activators such as axin and TRAP-1, respectively. This results in R-Smad phosphorylation and heterocomplex formation with Smad4 (Moustakas et al., 2001)

Figure 5: Smad-signaling centers. R-Smads (S) anchored to microtubules or filamin become mobilized toward SARA and the receptors where multiprotein centers are organized with the aid of scaffolding proteins containing PDZ domains, additional adaptors (Ad) and R-Smad and Smad4 (S4) anchors-activators such as axin and TRAP-1, respectively. This results in R-Smad phosphorylation and heterocomplex formation with Smad4 (Moustakas <i>et al</i><i>.</i>, 2001)