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Figure 4: Effects of TNF-α and N,N-dimethylsphingosine (DMS) on sphingosine kinase 1 and E-cadherin expression, MCF10A cell proliferation and invasion. (a) Real time-polymerase chain reaction, (b) western-blot, (c) cell proliferation, (d) cell invasion. (1) MCF-1, (2) MCF-10A + TNF-α; (3) MCF-10A+DMS + TNF-α; (4) MCF-10A-SPHK; (5) MCF-10A-SPHK + TNF-α; (6) MCF-10A-SPHK + DMS + TNF-α

Figure 4: Effects of TNF-α and N,N-dimethylsphingosine (DMS) on sphingosine kinase 1 and E-cadherin expression, MCF10A cell proliferation and invasion. (a) Real time-polymerase chain reaction, (b) western-blot, (c) cell proliferation, (d) cell invasion. (1) MCF-1, (2) MCF-10A + TNF-α; (3) MCF-10A+DMS + TNF-α; (4) MCF-10A-SPHK; (5) MCF-10A-SPHK + TNF-α; (6) MCF-10A-SPHK + DMS + TNF-α