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LETTER TO EDITOR
Year : 2008  |  Volume : 45  |  Issue : 2  |  Page : 72
 

Need for the appraisal of uncommon side effects of a commonly prescribed drug- Imatinib


1 Department of Medical Oncology, Yashoda Hospitals, Hyderabad, India
2 Department of Pathology, Osmania Medical College, Hyderabad, India
3 Department of Medicine, IMS, BHU, Varanasi, UP, India

Correspondence Address:
VSS Attili
Department of Medical Oncology, Yashoda Hospitals, Hyderabad,
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.41775

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How to cite this article:
Attili V, Anuradha V, Raju S. Need for the appraisal of uncommon side effects of a commonly prescribed drug- Imatinib. Indian J Cancer 2008;45:72

How to cite this URL:
Attili V, Anuradha V, Raju S. Need for the appraisal of uncommon side effects of a commonly prescribed drug- Imatinib. Indian J Cancer [serial online] 2008 [cited 2020 Oct 28];45:72. Available from: https://www.indianjcancer.com/text.asp?2008/45/2/72/41775


Dear Sir,

The concept of targeted therapy is emerging as an innovative, high potential new trend in cancer therapy. These drugs are not supposed to affect the normal cells and act selectively on cancer cells there by minimizing the systemic side-effects. However the results are not as expected. One of such novel drugs (first of its kind to be approved by FDA) is Imatinib, a Bcr-Abl tyrosine kinase inhibitor. It has been used in patients of chronic myeloid leukemia and Gastro Intestinal Stromal Tumor (GIST) and has been under evaluation for many more indications. It is usually well tolerated, with relatively minor toxicities like fluid retention and skin changes. However, with the time, oncologists are noticing newer side effects which were not reported in the initial phases of drug trials. The more recently reported ones are, Ototoxicity, [1] cardio toxicity [2] and optic neuritis. [3] It is probably due to the mitochondrial dysfunction as hypothesized by Grazette et al , in their in vitro studies. [4] This entity requires further attention as majority of the patients receiving therapy are relatively young, the therapy often leads to long disease-free survival and the toxicity [mitochondrial damage leading to cardio toxicity and neurotoxicity] results in considerable morbidity.

 
  References Top

1.Attili VS, Bapsy PP, Anupama G, Lokanatha D. Irreversible sensorineural hearing loss due to Imatinib. Leuk Res 2008;32:991-2.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Kerkela R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, et al . Cardiotoxicity of the cancer therapeutic agent Imatinib mesylate. Nat Med 2006;12:908-16.   Back to cited text no. 2    
3.Govind Babu K, Attili VS, Bapsy PP Anupama G. Imatinib-induced optic neuritis in a patient of chronic myeloid leukemia. Int Ophthalmol 2007;27:43-4.  Back to cited text no. 3    
4.Grazette LP, Kerkela R, Patten R. Imatinib mesylate (Gleevec) induces mitochondrial dysfunction and caspase activation in cardiac myocytes. J Card Fail 2005;11:S126.  Back to cited text no. 4    




 

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