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 ORIGINAL ARTICLE
Year : 2008  |  Volume : 45  |  Issue : 3  |  Page : 97-99

Oxidative stress in patients with laryngeal carcinoma


1 Department of Otorhinolaryngology, K.G.M.U., Lucknow, India; Head-Neck Unit, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK
2 Department of Otorhinolaryngology, K.G.M.U., Lucknow, India
3 Department of Internal Medicine, University of Mannitoba, Winnipeg, Canada
4 Division of Pharmacology, C.D.R.I., Lucknow, India

Correspondence Address:
R C Dwivedi
Department of Otorhinolaryngology, K.G.M.U., Lucknow, India; Head-Neck Unit, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-509X.44064

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Background : Cancer is a multifactorial disease. Repetitive cumulative damage of cellular organelles by oxy-free radicals are few of the important causative factors. Aim : To assess the role of oxidative stress in the laryngeal cancer patients in Indian population. Setting and Design : Case control study. Materials and Methods : Level of malondialdehyde (MDA) as a marker of oxidative stress was examined in large cohort of control (50) and laryngeal carcinoma patients (155) from North India. Both the controls and laryngeal carcinoma patients were smokers. Results : In control healthy subjects MDA levels were 0.102±0.07 (0.080- 0.303, 95% CI) n mol/ml, as compared to 0.329±0.16 (0.124-0.354, 95% CI) n mol/ml in the cases of laryngeal carcinoma patients. Three times higher serum MDA levels indicated that there was significant oxidative stress in the subjects having laryngeal carcinoma lesions. In addition patients with secondaries were having MDA levels of 0.4±0.02 (0.391-0.408 95% CI) n mol/ml, as compared to 0.57±0.03 (0.558-0.582 95% CI)n mol/ml in group of patients without secondaries. These two values were statistically significant as compared to control values (P<0.01). Conclusion : These findings suggest that in case of laryngeal carcinoma patients, there is increase in the level of oxidative enzyme MDA. The oxidative stress might be due to the modulation of pro-oxidant or anti-oxidant systems in laryngeal carcinoma.






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