| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 47
| Issue : 3 | Page : 317-321 |
Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population
Z Sabahi1, R Salek2, RE Heravi1, F Mosaffa1, ZJ Avanaki1, J Behravan1
1 Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad university of Medical Sciences, Mashhad, Iran
2 Omid and Imam Reza hospital, Cancer Research Center, Mashhad, Iran
Correspondence Address:
J Behravan
Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad university of Medical Sciences, Mashhad
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0019-509X.64723
Background: The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer. Objectives: The objective of this study was to find out the association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. Materials and Methods: In this study, 48 gastric cancer patients were diagnosed. Genomic DNA was extracted by a salting-out method. The MDR1 polymorphism was studied by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method, using a standard method. Results: The polymorphic homozygote (T/T) genotype showed significantly an association with the incidence of gastric cancer compared with controls (P < 0.05). Conclusions: This study suggests that C3435T polymorphism of the MDR1 gene may be associated with gastric cancer in an ethnic Iranian population.
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