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Year : 2016  |  Volume : 53  |  Issue : 2  |  Page : 225

In silico analysis to predict lack of carcinogenicity of Zika virus

1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Tropical Medicine, Hainan Medical University, Haikou, China

Date of Web Publication6-Jan-2017

Correspondence Address:
B Joob
Sanitation 1 Medical Academic Center, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.197711

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How to cite this article:
Joob B, Wiwanitkit V. In silico analysis to predict lack of carcinogenicity of Zika virus. Indian J Cancer 2016;53:225

How to cite this URL:
Joob B, Wiwanitkit V. In silico analysis to predict lack of carcinogenicity of Zika virus. Indian J Cancer [serial online] 2016 [cited 2022 May 21];53:225. Available from:

Sir, Zika virus is an emerging viral pathogen that causes the problem worldwide at present. The Zika virus infection can cause acute febrile hemorrhagic fever, and it can also induce fetal abnormality and congenital defect.[1],[2] The great concern on this new emerging disease is its effect on the cell that causes abnormal embryogenesis.[3] In oncology, another important concern is on the carcinogenicity property of the Zika virus infection. In fact, many viruses, such as hepatitis viruses, are proved to cause cancer in long-term. Here, the authors use standard in silico analysis for prediction of carcinogenicity of the Zika virus. The standard tool, Way2Drug, which is based on Prediction of Activity Spectra for Substances Technology.[4] Based on study on both cancer cell line and nontumor cell line condition, no carcinogenicity of the Zika virus can be seen. Based on this in silico study, it can imply that Zika virus should induce no malignancy. Further long-term study and observation on this topic are recommended. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

  References Top

Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health 2015;8:145-6. Wiwanitkit S, Wiwanitkit V. Acute viral hemorrhage disease: A summary on new viruses. J Acute Dis 2015;4:277-9. Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ 2016;352:i657. Pogodin PV, Lagunin AA, Filimonov DA, Poroikov VV. PASS Targets: Ligand-based multi-target computational system based on a public data and naïve Bayes approach. SAR QSAR Environ Res 2015;26:783-93.   Back to cited text no. 1

This article has been cited by
1 Anticancer property of Zika virus proteins: Lack of evidence from predictive clinical bioinformatics study
Beuy Joob, Viroj Wiwanitkit
Journal of Cancer Research and Therapeutics. 2021; 17(6): 1590
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