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| LETTER TO THE EDITOR |
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| Year : 2016 | Volume
: 53
| Issue : 2 | Page : 225 |
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In silico analysis to predict lack of carcinogenicity of Zika virus
B Joob1, V Wiwanitkit2
1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Tropical Medicine, Hainan Medical University, Haikou, China
| Date of Web Publication | 6-Jan-2017 |
Correspondence Address:
B Joob
Sanitation 1 Medical Academic Center, Bangkok
Thailand
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0019-509X.197711
How to cite this article:
Joob B, Wiwanitkit V. In silico analysis to predict lack of carcinogenicity of Zika virus. Indian J Cancer 2016;53:225 |
Sir,
Zika virus is an emerging viral pathogen that causes the problem worldwide at present. The Zika virus infection can cause acute febrile hemorrhagic fever, and it can also induce fetal abnormality and congenital defect.[1],[2] The great concern on this new emerging disease is its effect on the cell that causes abnormal embryogenesis.[3] In oncology, another important concern is on the carcinogenicity property of the Zika virus infection. In fact, many viruses, such as hepatitis viruses, are proved to cause cancer in long-term. Here, the authors use standard in silico analysis for prediction of carcinogenicity of the Zika virus. The standard tool, Way2Drug, which is based on Prediction of Activity Spectra for Substances Technology.[4] Based on study on both cancer cell line and nontumor cell line condition, no carcinogenicity of the Zika virus can be seen. Based on this in silico study, it can imply that Zika virus should induce no malignancy. Further long-term study and observation on this topic are recommended.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| » References | |  |
| 1. |
Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health 2015;8:145-6.
Wiwanitkit S, Wiwanitkit V. Acute viral hemorrhage disease: A summary on new viruses. J Acute Dis 2015;4:277-9.
Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ 2016;352:i657.
Pogodin PV, Lagunin AA, Filimonov DA, Poroikov VV. PASS Targets: Ligand-based multi-target computational system based on a public data and naïve Bayes approach. SAR QSAR Environ Res 2015;26:783-93.
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