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Year : 2006  |  Volume : 43  |  Issue : 3  |  Page : 110--116

Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India

R Aggarwal1, S Gupta1, R Nijhawan2, V Suri3, A Kaur4, V Bhasin5, SK Arora1 
1 Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
2 Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
3 Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
4 Primary Health Center, Manimajra, UT, Chandigarh, India
5 Obstetrics and Gynecology Department of General Multispeciality Hospital, Sector - 16, Chandigarh, India

Correspondence Address:
S K Arora
Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India

INTRODUCTION: Cervical cancer is the commonest cancer among Indian women. High-risk human papillomavirus (HPV) detection holds the potential to be used as a tool to identify women, at risk for subsequent development of cervical cancer. There is a pressing need for identifying prevalence of asymptomatic cervical HPV infection in the local population. OBJECTIVE: To determine the prevalence of high-risk HPV DNA in women with benign cervical cytology. MATERIALS AND METHODS: Women visiting the gynecology outpatient with varied complaints were subjected to Pap smear. Four hundred and seventy two samples were subjected to polymerase chain reaction, using consensus primers for low and high-risk HPV (types 6, 11, 16, 18, 31 and 33). The samples that were positive for HPV DNA were subsequently assessed for high-risk consensus primers, types 16, 18, 31 and 33 as well as for HPV type 16 and 18. RESULTS: One hundred and seventy four (36.8%) women tested positive for HPV DNA. Thirty nine (8.2%) of the entire cohort tested positive for high-risk HPV. Fifteen samples were positive for type 16, 22 for type 18 and two for both types 16 and 18. A statistically higher prevalence of high-risk HPV was observed in poorly educated and rural groups. No association of HPV prevalence was noted with age, parity and age at marriage. CONCLUSION: The study generates epidemiological data of prevalence of sub-clinical HPV in the women visiting a tertiary care institute as well as peripheral health centres. The data generated will be useful for laying guidelines for mass screening of HPV, treatment and prophylaxis in the local population.


How to cite this article:
Aggarwal R, Gupta S, Nijhawan R, Suri V, Kaur A, Bhasin V, Arora S K. Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India.Indian J Cancer 2006;43:110-116


How to cite this URL:
Aggarwal R, Gupta S, Nijhawan R, Suri V, Kaur A, Bhasin V, Arora S K. Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India. Indian J Cancer [serial online] 2006 [cited 2021 Jan 16 ];43:110-116
Available from: https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2006;volume=43;issue=3;spage=110;epage=116;aulast=Aggarwal;type=0