Indian Journal of Cancer Home 

ORIGINAL ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2006  |  Volume : 43  |  Issue : 3  |  Page : 117--121

Neoadjuvant chemotherapy followed by surgical cytoreduction in advanced epithelial ovarian cancer

SVS Deo1, Hemant Goyal1, NK Shukla1, V Raina2, Lalit Kumar2, G Srinivas1 
1 Department of Surgical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
2 Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
SVS Deo
Department of Surgical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi
India

AIMS: To study the role of neoadjuvant chemotherapy (NACT) followed by surgical cytoreduction in the management of advanced epithelial ovarian cancers. MATERIALS AND METHODS: A retrospective analysis of 82 patients with advanced epithelial ovarian cancers (stage IIIC and IV) who were treated with NACT followed by surgical cytoreduction between 1995 and 2004 was performed. Response to NACT, optimal cytoreduction rate, disease-free survival and overall survival were analyzed. RESULTS: There were 59 patients (72%) with stage IIIC disease and 23 (28%) with stage IV disease. Diagnosis was established by imaging, ascitic fluid cytology and CA-125 estimations in 75% and by laparotomy in 25% of the patients. After NACT, complete response occurred in 17 patients (20.7%), 50 (61.0%) had partial response and no response was documented in 15 (18.3%) patients. Optimal surgical cytoreduction could be achieved in 72% of the patients. At the median follow-up of 34 months (range 6-102 months), 5-year disease-free and overall survivals were 31 and 32% respectively. The median disease free interval was 25.4 months. On multivariate analysis, degree of optimal cytoreduction was the only factor ( P <0.05) affecting survival. CONCLUSIONS: NACT followed by surgical cytoreduction is a promising treatment strategy for the management of advanced epithelial ovarian cancers. A significant number of patients exhibit response to NACT. Downstaging following NACT leads to higher optimal cytoreduction rates and improved survival in comparison to historical controls.


How to cite this article:
Deo S, Goyal H, Shukla N K, Raina V, Kumar L, Srinivas G. Neoadjuvant chemotherapy followed by surgical cytoreduction in advanced epithelial ovarian cancer.Indian J Cancer 2006;43:117-121


How to cite this URL:
Deo S, Goyal H, Shukla N K, Raina V, Kumar L, Srinivas G. Neoadjuvant chemotherapy followed by surgical cytoreduction in advanced epithelial ovarian cancer. Indian J Cancer [serial online] 2006 [cited 2020 Nov 27 ];43:117-121
Available from: https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2006;volume=43;issue=3;spage=117;epage=121;aulast=Deo;type=0