Indian Journal of Cancer
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   2011| January-March  | Volume 48 | Issue 1  
    Online since February 10, 2011

 
 
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LETTERS TO EDITOR
Malignant priapism secondary to osteogenic sarcoma
RB Nerli, A Koura, V Prabha, SB Alur, S Devaraju, S Godhi, MB Hiremath
January-March 2011, 48(1):111-112
DOI:10.4103/0019-509X.76628  PMID:21330752
  21,221 377 4
ORIGINAL ARTICLES
Spirituality, distress, depression, anxiety, and quality of life in patients with advanced cancer
A Kandasamy, SK Chaturvedi, G Desai
January-March 2011, 48(1):55-59
DOI:10.4103/0019-509X.75828  PMID:21248445
Objective: To study the influence of spiritual well being (Sp WB) on symptoms of distress, depression, and other dimensions of quality of life in advanced cancer patients receiving palliative care. Materials and Methods: The study was cross-sectional in nature. Fifty patients with advanced cancer from a hospice were assessed with the following instruments: the visual analog scale for pain (VAP), M.D. Anderson symptom inventory (MDASI), Hospital Anxiety Depression Scale (HADS), Functional assessment of cancer therapy - Palliative Care (FACT-pal), and Functional assessment of chronic illness therapy-spiritual well-being (FACIT-sp). We studied the correlations between spirituality and other variables on these scales. Results: Depression and anxiety were negatively correlated with spiritual well-being (Sp WB). Sp WB was significantly correlated with fatigue (r = -0.423, P = 0.002), symptom distress (r = -0.717, P < 0.001), memory disturbance (r = -0.520, P < 0.001), loss of appetite (r = -0.399, P = 0.004), drowsiness (r = -0.400, P = 0.004), dry mouth (r = -0.381, P = 0.006), and sadness (r = -0.720, P < 0.001). Sp WB was positively correlated with all the other aspects of QOL measures. Predictors such as palliative care well-being (t = 2.840, P = 0.008), distress (t = -2.582, P = 0.015), sadness (t = -2.765, P = 0.010), mood (t = 2.440, P = 0.021), and enjoyment in life (t = -3.586, P = 0.001) were significantly correlated with Sp WB, after regression analysis. Conclusions: This study suggests that spiritual well being is an important component of the quality of life of advanced cancer patients, and is closely related to the physical and psychological symptoms of distress. It should be addressed appropriately and adequately in palliative care settings.
  16,161 1,384 67
SYMPOSIUM
Brain tumor and Gliadel wafer treatment
M Panigrahi, PK Das, PM Parikh
January-March 2011, 48(1):11-17
DOI:10.4103/0019-509X.76623  PMID:21330749
Glioblastoma is a rapidly progressive and extremely fatal form of brain tumor with poor prognosis. It is the most common type of primary brain tumor. Even with the most aggressive conventional treatment that comprises surgery followed by radiotherapy and chemotherapy, most patients die within a year of diagnosis. Developments in molecular and cell biology have led to better understanding of tumor development, leading to novel treatment strategies including biological therapy and immunotherapy to combat the deadly disease. Targeted drug delivery strategies to circumvent the blood-brain barrier have shown efficiency in clinical trials. Gliadel wafer is a new approach to the treatment of glioblastoma, which involves controlled release delivery of carmustine from biodegradable polymer wafers. It has shown promising results and provides a silver lining for glioblastoma patients.
  9,715 661 19
REVIEW ARTICLES
A brief review of voice restoration following total laryngectomy
M Kapila, N Deore, RS Palav, RA Kazi, RP Shah, MV Jagade
January-March 2011, 48(1):99-104
DOI:10.4103/0019-509X.75841  PMID:21248437
Despite advances in conservative laryngeal surgery and radiotherapy, total laryngectomy still remains the procedure of choice for advanced-stage (UICC T3 and T4) laryngeal carcinoma, around the world. The functional rehabilitation of the laryngectomized patients has been a concern of head and neck surgeons and speech therapists. Significant developments in speech rehabilitation over the past three decades have led to substantial improvements in the quality of life of these patients. The tracheoesophageal (TE) voice prosthesis has become the gold standard in various centers for voice rehabilitation since its introduction in 1980. Successful tracheoesophageal voice restoration in laryngectomy patients can be very rewarding and patients no longer have to live in silence while they await the results of their cancer treatments. They can face the challenges of life with the knowledge that a near normal quality of life is very much possible.In this article, we present a brief review of voice restoration following laryngectomy.
  8,562 547 10
Preoperative assessment and optimization in periampullary and pancreatic cancer
S Myatra, JV Divatia, B Jibhkate, GS Barreto, SV Shrikhande
January-March 2011, 48(1):86-93
DOI:10.4103/0019-509X.75839  PMID:21248439
Perioperative management of pancreatic and periampullary cancer poses a considerable challenge to the pancreatic surgeon, anesthesiologist, and the intensive care team. The preoperative surgical evaluation of a pancreatic lesion aims to define the nature of the lesion (malignant or benign), stage the tumor, and to determine resectability or other non-surgical treatment options. Patients are often elderly and may have significant comorbidities and malnutrition. Obstructive jaundice may lead to coagulopathy, infection, renal dysfunction, and adverse outcomes. Routine preoperative biliary drainage can result in higher complication rates, and metal stents may be preferred over plastic stents in selected patients with resectable disease. Judicious use of antibiotics and maintaining fluid volume preoperatively can reduce the incidence of infection and renal dysfunction, respectively. Perioperative fluid therapy with hemodynamic optimization using minimally invasive monitoring may help improve outcomes. Careful patient selection, appropriate preoperative evaluation and optimization can greatly contribute to a favorable outcome after major pancreatic resections.
  7,872 834 5
ORIGINAL ARTICLES
Role of RT-PCR and FISH in diagnosis and monitoring of acute promyelocytic leukemia
S Polampalli, A Choughule, K Prabhash, P Amare, C Baisane, S Kabre, S Mahadik, S Shinde, R Nair, S Banavali
January-March 2011, 48(1):60-67
DOI:10.4103/0019-509X.75831  PMID:21248444
Background: Patients with a presence of Promyelocytic Leukemia-Retinoic Acid Receptor Alpha (PML-RARA) genes rearrangement predict a favorable response to all-trans retinoic acid (ATRA), and a significant improvement in survival. Therefore, establishing the presence of PML-RARA rearrangement is important for optimal patient management. Aim: The objective of this study is to compare and assess the role of fluorescent in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) in the diagnosis and long-term monitoring of Acute Promyelocytic Leukemia (APL). Materials and Methods: We compared 145 samples received at different interval of times to analyze the sensitivity of RT-PCR and FISH. Results: The failure rate for RT-PCR was 4% at baseline, 13% at induction, and 0% at the end of consolidation. And for FISH it was 8% at baseline, 38% at induction, and 66% at the end of consolidation. The predictive values of relapse in the patients who were positive and negative by RT-PCR, at the end of induction, were 60 % and 3%, respectively, and at end of consolidation it was 67 % and 4%, respectively. On the other hand the predictive values of relapse in patients who were positive and negative by FISH at end of induction were 57 % and 6%, respectively; while at end of consolidation it was 14% who were negative by FISH. Conclusion: Both RT-PCR and FISH are important for the diagnosis of APL cases, as both techniques complement each other in the absence or failure of any one of them. However, RT-PCR is more sensitive than FISH for the detection of minimal residual disease in the long-term monitoring of these patients. The present study shows that the predictive value of relapse is more associated with minimal residual disease (MRD) results by RT-PCR than that by FISH.
  7,517 531 6
SYMPOSIUM
Optimising management of cancer related anemia
K Prabhash, S Nag, S Patil, PM Parikh
January-March 2011, 48(1):1-10
DOI:10.4103/0019-509X.76622  PMID:21330748
This review article provides the current recommendations and evidence for the correct management of anemia in cancer patients. The various options available include transfusions, iron and erythropoiesis stimulation. The indications, pros and cons of each option are discussed.
  7,048 651 1
REVIEW ARTICLES
Helicobacter pylori infection in relation to gastric cancer progression
A Venkateshwari, D Krishnaveni, S Venugopal, P Shashikumar, A Vidyasagar, A Jyothy
January-March 2011, 48(1):94-98
DOI:10.4103/0019-509X.75840  PMID:21248438
Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.
  7,034 570 17
SYMPOSIUM
Selective internal radiation therapy: 90 Y (yttrium) labeled microspheres for liver malignancies (primary and metastatic)
MC Uthappa, R Ravikumar, A Gupta
January-March 2011, 48(1):18-23
DOI:10.4103/0019-509X.76625  PMID:21330750
Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors including carcinoid tumors, lung, breast, sarcoma, colon, hepatocellular and ocular melanoma. Its clinical benefit can be as much as 85%, survival can be doubled and patients with extensive colorectal metastases not amenable to resection or ablation can be offered a 32% chance of surviving for 18 months. Ongoing and future studies will refine our understanding of optimizing patient eligibility, dosage, frequency as well as novel applications.
  7,009 483 3
LETTERS TO EDITOR
Carcinoma esophagus with isolated metatarsal metastasis
A Mohanty, D Dutta, S Das, DR Samanta, S Senapati
January-March 2011, 48(1):112-113
DOI:10.4103/0019-509X.76630  PMID:21330753
  7,053 317 1
ORIGINAL ARTICLES
Role of cetuximab and sorafenib in treatment of metastatic colorectal cancer
KM Galal, Z Khaled, Abdel Monem M Mourad
January-March 2011, 48(1):47-54
DOI:10.4103/0019-509X.75825  PMID:21248446
Background: The relationship of epidermal growth factor receptors (EGFR) pathway, such as PI3K, K-ras, and B-raf, with response to EGFR-targeted antibodies is less well studied. Aim: To assess sorafenib with cetuximab in treating metastatic colorectal cancer. Settings and Design: Thirty-five patients with metastatic colorectal cancer were randomized to receive cetuximab with or without oral sorafenib. Patients and Methods: Patients received cetuximab IV weekly for four weeks and oral sorafenib twice daily on days 1 - 28, with recycling every four weeks. The primary end point was the response rate (partial and complete), while the secondary end points were the adverse effects, time to progression and overall survival. Statistical Analysis was made using the Statistical Product and Service Solutions, using SPSS 10.0, with estimation of both time to progression and overall survival time by the Kaplan-Meier method and comparing the two groups with the use of a log-rank test. Results: Partial response was higher in cetuximab-sorafenib (EN), which constituted 33.3% compared to 17.6% in the cetuximab group (P = 0.44). Progression-free survival had a statistically higher significant difference in wild K-ras compared to mutant K-ras cases (P = .0001). Median overall survival was seven and five months in the (EN) and (E) groups respectively (P = 0.49). Conclusion: K-ras and B-raf was a predictor of response, so genotyping of tumors was needed for defining the patient population that was likely to benefit from the targeted therapy. A combination of therapy that simultaneously targets K-ras and B-raf could be a useful approach to increase the number of patients who may benefit from anti-EGFR therapy.
  6,045 584 20
LETTERS TO EDITOR
Solitary giant cystic liver metastasis mimicking an abscess - A word of caution
V Singla, V Virmani, P Dey, N Khandelwal
January-March 2011, 48(1):127-129
DOI:10.4103/0019-509X.76642  PMID:21330763
  6,339 267 1
A rare case of Hodgkin's breast lymphoma masquerading as locally advanced breast carcinoma
K Rahmat, CH Yip, NR D'Cruz, KJ Jayaprasagam, KT Wong, F Moosa
January-March 2011, 48(1):118-120
DOI:10.4103/0019-509X.76634  PMID:21330757
  5,923 342 -
ORIGINAL ARTICLES
Tetany: Possible adverse effect of bevacizumab
SR Anwikar, MS Bandekar, TK Patel, PB Patel, NA Kshirsagar
January-March 2011, 48(1):31-33
DOI:10.4103/0019-509X.75819  PMID:21248449
Background: Bevacizumab a recombinant humanized monoclonal antibody was approved in 2004 by US FDA for metastatic colorectal cancer. It is reported to cause potentially serious toxicities including severe hypertension, proteinuria, and congestive heart failure. Aim: To correlate adverse event tetany with the use of bevacizumab. Materials and Methods : World Health Organization's Uppsala Monitoring Centre, Sweden, for reporting of adverse drug reactions from all over the world, identified 7 cases with tetany-related symptoms to bevacizumab from four different countries. These 7 patients reported to UMC database developed adverse events described as musculoskeletal stiffness (1), muscle spasm (1), muscle cramps (1), lock jaw or jaw stiffness (4), and hypertonia (1), with hypocalcaemia. Results: After detailed study of the possible mechanism of actions of bevacizumab and factors causing tetany, it is proposed that there is a possibility of tetany by bevacizumab, which may occur by interfering with calcium metabolism. Resorption of bone through osteoclasts by affecting VEGF may interfere with calcium metabolism. Another possibility of tetany may be due to associated hypomagnesaemia, hypokalemia, or hyponatremia. Conclusions: Tetany should be considered as a one of the signs. Patient on bevacizumab should carefully watch for tetany-related symptoms and calcium and magnesium levels for their safety.
  5,196 399 6
Outcome of combined modality treatment including neoadjuvant chemotherapy of 128 cases of locally advanced breast cancer: Data from a tertiary cancer center in northern India
V Raina, M Kunjahari, NK Shukla, SVS Deo, A Sharma, BK Mohanti, DN Sharma
January-March 2011, 48(1):80-85
DOI:10.4103/0019-509X.75838  PMID:21248440
Background: Breast cancer is now the most common cancer in many parts of India and the incidence varies from 12 to 31/100000, and is rising. Locally advanced breast cancer (LABC) accounts for 30 - 35% of all cases of breast cancers in India. LABC continues to present a challenge and imposes a major health impact in our country. Materials and Methods: We carried out a analysis of our LABC patients who received neoadjuvant chemotherapy (NACT) at our hospital over a 10-year period, from January 1995 to December 2004. We analyzed the response to NACT, disease-free survival (DFS), and overall survival (OS). Results: Patients with stages IIIA, IIIB, and IIIC were included. LABC comprised of 26.24% (609 patients) of new patients. One hundred and twenty-eight (31.1%) patients received NACT. Median age was 48 years and estrogen receptor was positive in 64%. Chemotherapy protocol was an FEC (5-Fluorouracil, Epirubicin, Cyclophosphamide) regimen in the following doses: Cyclophosphamide 600 mg/m2, 5-FU 600 mg/m2, and Epirubicin 75 mg/m2 given every three weeks, six doses, followed by modified radical mastectomy (MRM) and locoregional radiotherapy. The overall response rate (complete response (CR) + partial response (PR)) was 84.4%, clinical CR (cCR) was 13.3% and pathological CR (pCR) was 7.8%. Median DFS and OS were 33 and 101 months, respectively. The disease-free survival (DFS) and overall survival (OS) at five years were 41 and 58%, respectively. Conclusions: This study analyzes the outcome in patients who received NACT, in the largest number of LABC patients from a single center in India, and our results are comparable to the results reported from other centers.
  4,894 508 11
LETTERS TO EDITOR
Giant mesenteric fibromatosis in Gardner's syndrome
BA Vaswani, M Shah, PM Shah, BJ Parikh, AS Anand, GL Sharma
January-March 2011, 48(1):140-142
DOI:10.4103/0019-509X.76652  PMID:21330771
  4,767 268 6
ORIGINAL ARTICLES
Correlates of cervical cancer screening among underserved women
YD Chankapa, R Pal, D Tsering
January-March 2011, 48(1):40-46
DOI:10.4103/0019-509X.75823  PMID:21248447
Background and Objectives: Substantial subgroups of Indian women, specifically those of ethnic minorities, had not been screened for cervical cancer or are not screened at regular intervals. We aim to find out the magnitude of cervical cancer and precancerous lesions among women in the age group 15-60 years, and to identify the various socio-demographic and reproductive correlates among those with the cervical lesions. Patients and Methods: Nine hundred and sixty-eight adult women in the age group 15−60 years were selected by simple random sampling technique in a population based descriptive cross-sectional study in a cervical cancer screening camp in a primary health center at the East Sikkim, during 1st September to 30th November 2006. Main outcome measures were the extent and correlates of cervical cancer without any interventions. The data collection tool used for the study was a pre-tested questionnaire prepared prior to the study for ensuring feasibility, acceptability, time management, validity and reliability. Information on socio-demographic and reproductive variables was collected by interview method using this questionnaire. Results: Out of 968 women in the study population, overwhelming majority 921 (95.15%) had no overt or pre-cancerous cervical lesion. Only 47 were found to have changes in their cervical epithelium. None of these 47 women was proved dyskaryotic on cytopathological screening of the cervical smear. No significant difference was noted among those with or without lesions among women below 30 years of age with those above, among illiterate women with literates, in per capita monthly family income difference, age at marriage and childbirth. Low-grade and high-grade squamous intraepithelial cervical lesions were associated with Hindu women only and were related with past history of abortion and still birth in women significantly. Conclusion: There was an imperative need for identifying prevalence of asymptomatic cervical dysplasia in all population.
  4,416 486 4
REVIEW ARTICLES
Integrating the geographic information system into cancer research
AT Najafabadi, M Pourhassan
January-March 2011, 48(1):105-109
DOI:10.4103/0019-509X.75834  PMID:21248443
Cancer control researchers seek to reduce the burden of cancer by studying interventions, their impact on defined populations, and the means by which they can be better used. The first step in cancer control is identifying where the cancer burden is elevated, which suggests locations where interventions are needed. Geographic information systems (GIS) and other spatial analytic methods provide such a solution and thus can play a major role in cancer control. The purpose of this article is to examine the impact of GIS on the direction of cancer research. It will consider the application of GIS techniques to research in cancer etiology.
  4,303 401 4
ORIGINAL ARTICLES
Comparative study of the toxicity of 5-fluorouracil-adriamycin-cyclophosphamide versus adriamycin-cyclophosphamide followed by paclitaxel in carcinoma breast
Dhanya S Palappallil, Bindu Latha R Nair, KL Jayakumar, Ramani T Puvathalil
January-March 2011, 48(1):68-73
DOI:10.4103/0019-509X.75836  PMID:21248442
Context: When cure is possible treatment should be undertaken despite life-threatening toxicities. Fluorouracil-Adriamycin-Cyclophosphamide (FAC) and Adriamycin-Cyclophosphamide (AC-P) are two popular regimens used in the treatment of carcinoma breast and the data regarding the toxicity profile of the AC-P regimen is scarce in the South Indian population. Aims: To study the severity of different types of toxicities seen in patients on FAC and AC-P regimens, to grade the toxicity according to the World Health Organization (WHO) toxicity grading, and to compare the same. Settings and Design: A prospective observational study, with 50 patients in each regimen, was conducted in the Department of Radiotherapy between February 2007 and July 2008. Materials and Methods: The high risk patients received the AC-P regimen and the rest received the FAC regimen. The toxicities developed were graded according to the WHO guidelines. Statistical Analysis Used: The data was analyzed using the chi square test in SPSS 16. Results: Anemia, hyperpigmentation, stomatitis, and diarrhea were significantly high (P < 0.05) in patients receiving the FAC regimen, whereas, leukopenia, myalgia, arthralgia and peripheral neuropathy were significantly high (P <0.05) in patients receiving the AC-P regimen. The Karnofsky performance status was higher in patients receiving the AC-P regimen. Conclusions: Although both the regimens had different toxicity profiles the quality of life was better for patients on the AC-P regimen.
  4,187 440 5
Eight-year experience in esophageal cancer surgery
B Thakur, Chun Shan Zhang, Xian Li Meng, S Bhaktaman, S Bhurtel, P Khakural
January-March 2011, 48(1):34-39
DOI:10.4103/0019-509X.75821  PMID:21248448
Aim: Esophageal cancer remains a major and lethal health problem. In Nepal, not much has been explored about its management. The aim of this study was to conduct a retrospective review of esophageal cancer patients undergoing surgery or combined modality treatment at a cancer hospital in Nepal. Materials and Methods: Resectable cases were treated primarily with surgery. Locally advanced cases with doubtful or obviously unresectability underwent preoperative chemo/radiation or chemoradiation followed by surgery. Results: Among 900 patients, 103 were treated with curative intent. Mean age of patients was 54 years, and 100% of the patients presented with complaint of dysphagia. Surgery as a single modality of treatment was done in 57% of cases, and the remaining underwent combined modality treatment. Transthoracic and transhiatal approaches were used in 95% and 5% of cases, respectively. Nodal sampling, two-field (2-FD), and three-field lymphadenectomy (3-FD) were done in 18%, 59%, and 20% of cases, respectively. A majority of patients had pathological stage III disease (46.6%). In-hospitality mortality was 5%, and anastomotic leakage rate was 14%. In 87% of patients, R0 resection was achieved. Overall, 4-year survival was 20%. A R0 resection, early-stage disease and 3-FD favored the survival advantage (P < 0.05). Conclusion: The mortality, complication, and survival results were in the acceptable range. R0 resection and radical nodal dissection should be standard practice.
  4,249 338 3
Evaluation of carbamate insecticides as chemotherapeutic agents for cancer
Mohd. Amanullah , Babu Y Hari
January-March 2011, 48(1):74-79
DOI:10.4103/0019-509X.75837  PMID:21248441
Background: Cancer chemotherapy has already been in practice by the use of toxins and some of the specific poisonous compounds of cyanide derivatives. Carbamate insecticides inhibit cellular metabolism including energy, protein, and nucleic acid metabolism, thereby, causing cell regression and death. Aim: Preliminary evaluation of three carbamate insecticides, namely, baygon, carbaryl, and carbofuran as chemotherapeutic agents for cancer is undertaken in the present study. Materials and Methods: The toxicity of carbamates on squamous cell carcinoma was assessed in-vitro using dye binding tests. Cells were grown in microtitration ELISA plates, as adherent cultures, for six hours, and then exposed to the drugs for 2, 4, 8, and 12 hours, and finally stained with neutral red, to assess the viable cell number, and with methylene blue for the determination of protein in the monolayer. Optical density was read in an ELISA reader. Statistical Analysis: The data obtained during the experiment was subjected to statistical analysis by using the student 't' test. Results: The results indicated that the percentage of the viable cell number reduced with an increase in the time of exposure of the drugs. Exposure of the tumor cells to the drugs for 12 hours detached them completely from the wells, and hence, all the cells were washed out. Exposure of the drugs prior to the establishment of the culture in-vitro resulted in the non-formation of the monolayer in the wells. Conclusions: Among the three drugs studied, the survival percent was least with carbaryl treatment followed by baygon, and with carbofuran treatment it was almost near to control group.
  4,044 285 4
Postoperative chemoradiation in patients with localized gastric adenocarcinoma: Single center experience
A Yoney, Y Bati, L Isikli, M Unsal
January-March 2011, 48(1):24-30
DOI:10.4103/0019-509X.75816  PMID:21248450
Background : 5-Flourouracil (FU)-based chemotherapy (CT) and concurrent 45 Gy radiotherapy (RT) is one of the standard postoperative approaches currently used in gastric carcinoma. The high toxicity rates of this treatment leads to interruption of treatment in the majority of patients. In our study, we investigated the rates of toxicity and treatment discontinuation observed during postoperative FU-based chemoradiotherapy (CRT); retrospectively evaluated the effect of CRT and the other prognostic factors on local and distant control and survival. Patients and Methods: A total of 160 patients consisting of 97 total and 63 subtotal gastrectomy receiving postoperative CRT, have been studied retrospectively. Results : Patients who had to discontinue the treatment for a median of 6 (range, 3-13) days experienced toxicity during treatment at a rate of 43%. During the 21 (range, 4-68) months of follow-up local recurrences were observed in 8 (5%) patients and distant recurrences were observed in 41 (25.6%) patients. While the 1-3 year overall survival (OS) rates were 75% and 42%, 13-year disease-free survival (DFS) rates were 63% and 42%, respectively. In the univariate analysis for OS and DFS demonstrated statistical significance for below those 60 years of age, D1-D2 dissection type, negative surgical margin, early treatment beginning, the absence of invasion, and early stage disease. D1D2 dissection type, early treatment begining, age below 60 years and early stage disease significantly improve OS and DFS in multivarite analysis. Conclusions: Survival is worse in patients older than 60 years, had late treatment begining, advanced stage and D0 dissection.
  3,941 374 -
LETTERS TO EDITOR
Colitis and colonic perforation in a patient with breast carcinoma treated with taxane based chemotherapy
KS Sodhi, SK Aiyappan, G Singh, M Prakash, N Khandelwal
January-March 2011, 48(1):134-135
DOI:10.4103/0019-509X.76647  PMID:21330767
  3,799 264 3
Enteropathy-associated T-cell lymphoma in a patient without a prior diagnosis of celiac disease: A diagnostic conundrum
S Jacob, D Mohapatra, ML Nordberg, JD Cotelingam, S Upadhyay, D Japa
January-March 2011, 48(1):124-125
DOI:10.4103/0019-509X.76640  PMID:21330761
  3,768 229 -
Cancer in porcelain gallbladder - Rare imaging trait
KK Sen, A Upadhyaya, Y Pimpalwar, J D'souza
January-March 2011, 48(1):132-134
DOI:10.4103/0019-509X.76646  PMID:21330766
  3,700 295 2
Bowen's disease over the abdomen - A histological pigmented variety
VV Pai, K Hanumanthayya, KN Naveen, R Rao, US Dinesh
January-March 2011, 48(1):121-122
DOI:10.4103/0019-509X.76637  PMID:21330759
  3,586 325 1
Olfactory neuroblastoma with central nervous system metastasis-A rare report
B Rai, AK Pandey, R Aggarwal, K Dimri
January-March 2011, 48(1):115-116
DOI:10.4103/0019-509X.76632  PMID:21330755
  3,572 290 1
CT findings of primary extra-intestinal gastrointestinal stromal tumor of greater omentum with extensive peritoneal and bilateral ovarian metastases
G Jindal, R Rastogi, S Kachhawa, GL Meena
January-March 2011, 48(1):135-137
DOI:10.4103/0019-509X.76648  PMID:21330768
  3,546 257 3
Aggressive digital papillary adenocarcinoma
M Rastrelli, J Soteldo, GC Vitali, G Mazzarol, G Trifirņ, G Tosti, A Testori
January-March 2011, 48(1):126-127
DOI:10.4103/0019-509X.76641  PMID:21330762
  3,447 246 7
Lymphangiomatosis of the colon mimicking acute appendicitis
Mehmet Ali Yagci, Atakan Sezer, Eyup Yeldan, I Coskun, Ahmet Rahmi Hatipoglu, Semsi Altaner, Hasan Umit
January-March 2011, 48(1):139-140
DOI:10.4103/0019-509X.76651  PMID:21330770
  3,213 234 2
Angiocentric NK/T-cell lymphoma mimicking pyoderma gangrenosum
PO Emanuel, SE Mercer
January-March 2011, 48(1):113-115
DOI:10.4103/0019-509X.76631  PMID:21330754
  2,810 299 2
Gliosarcoma with rhabdomyomatous differentiation: A case report
S Sethi, F Siraj, S Roy
January-March 2011, 48(1):129-131
DOI:10.4103/0019-509X.76643  PMID:21330764
  2,804 246 4
Aspergillus - The great masquerader
U Devaraj, R Priya, J Savio, GA Dsouza
January-March 2011, 48(1):137-138
DOI:10.4103/0019-509X.76650  PMID:21330769
  2,609 247 -
Fusarial skin lesion in immunocompromised
SB Gurusidappa, HS Mamatha
January-March 2011, 48(1):116-117
DOI:10.4103/0019-509X.76633  PMID:21330756
  2,631 219 4
An unusual variant of leiomyoma masquerading peroperatively as sarcoma
S Aggarwal, VK Arora
January-March 2011, 48(1):120-121
DOI:10.4103/0019-509X.76636  PMID:21330758
  2,567 218 2
Role of adjuvant radiation therapy in unusually rare primary malignant osteoclast-like giant cell tumor of the kidney
MS Tiwana, S Kakkar, N Shirazi, P Upadhya, H Nautiyal
January-March 2011, 48(1):123-124
DOI:10.4103/0019-509X.76638  PMID:21330760
  2,501 217 2
New adjusted cut-off level for serum prostate specific antigen
V Wiwanitkit
January-March 2011, 48(1):110-110
DOI:10.4103/0019-509X.76626  PMID:21330751
  2,383 235 -
Nephrotic syndrome in plasma cell leukaemia - A rare presentation
M Diogo, C Faustino, T Pimentel, J Amorim, i Tavares
January-March 2011, 48(1):131-132
DOI:10.4103/0019-509X.76644  PMID:21330765
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